Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture

[Image: see text] The NLRP3 inflammasome plays a role in the inflammatory response to vaccines, in antimicrobial host defense, and in autoimmune diseases. However, its mechanism of action remains incompletely understood. NLRP3 has been shown to be activated by diverse stimuli including microbial tox...

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Detalles Bibliográficos
Autores principales: Manna, Saikat, Howitz, William J., Oldenhuis, Nathan J., Eldredge, Alexander C., Shen, Jingjing, Nihesh, Fnu Naorem, Lodoen, Melissa B., Guan, Zhibin, Esser-Kahn, Aaron P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107863/
https://www.ncbi.nlm.nih.gov/pubmed/30159395
http://dx.doi.org/10.1021/acscentsci.8b00218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107863/
https://www.ncbi.nlm.nih.gov/pubmed/30159395
http://dx.doi.org/10.1021/acscentsci.8b00218

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