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PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD(+) levels and increasing SIRT1 activity

BACKGROUND: Nicotinamide adenine dinucleotide (NAD(+)) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD(+) levels and play essential roles in regulating metabolism. However, there has been little researc...

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Detalles Bibliográficos
Autores principales:	Zha, Siyuan, Li, Zhen, Cao, Qing, Wang, Fei, Liu, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107962/ https://www.ncbi.nlm.nih.gov/pubmed/30139380 http://dx.doi.org/10.1186/s13287-018-0961-7

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