Cargando…

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD(+) levels and increasing SIRT1 activity

BACKGROUND: Nicotinamide adenine dinucleotide (NAD(+)) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD(+) levels and play essential roles in regulating metabolism. However, there has been little researc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zha, Siyuan, Li, Zhen, Cao, Qing, Wang, Fei, Liu, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107962/ https://www.ncbi.nlm.nih.gov/pubmed/30139380 http://dx.doi.org/10.1186/s13287-018-0961-7

Ejemplares similares

Correction to: PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD(+) levels and increasing SIRT1 activity
por: Zha, Siyuan, et al.
Publicado: (2018)

Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34
por: Sahaboglu, Ayse, et al.
Publicado: (2017)

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells
por: Bai, Xue Tao, et al.
Publicado: (2015)

PARP Inhibitor PJ34 Suppresses Osteogenic Differentiation in Mouse Mesenchymal Stem Cells by Modulating BMP-2 Signaling Pathway
por: Kishi, Yuta, et al.
Publicado: (2015)

Ginsenoside Rb1 Attenuates High Glucose-Induced Oxidative Injury via the NAD-PARP-SIRT Axis in Rat Retinal Capillary Endothelial Cells
por: Fan, Chunlan, et al.
Publicado: (2019)

Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2017)

Pneumocystis jirovecii (Pj) quantitative PCR to differentiate Pj pneumonia from Pj colonization in immunocompromised patients
por: Maillet, M., et al.
Publicado: (2013)

Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis
por: Espinoza-Derout, Jorge, et al.
Publicado: (2019)

PJ accu (?)
Publicado: (1989)

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2018)

The taming of PARP1 and its impact on NAD(+) metabolism
por: Hurtado-Bagès, Sarah, et al.
Publicado: (2020)

Discovery of an NAD(+) analogue with enhanced specificity for PARP1
por: Zhang, Xiao-Nan, et al.
Publicado: (2022)

Influence of PJ34 on the genotoxicity induced by melphalan in human multiple myeloma cells
por: Xiong, Ting, et al.
Publicado: (2015)

CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
por: Hu, Xuebin, et al.
Publicado: (2018)

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells
por: Cseh, Anna Maria, et al.
Publicado: (2019)

Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
por: Shen, Yan, et al.
Publicado: (2016)

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts
por: Visochek, Leonid, et al.
Publicado: (2019)

SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure
por: Buonvicino, Daniela, et al.
Publicado: (2021)

The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells
por: Cohen-Armon, Malka
Publicado: (2020)

Correction: The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts
por: Visochek, Leonid, et al.
Publicado: (2020)

Rebalancing of mitochondrial homeostasis through an NAD(+)-SIRT1 pathway preserves intestinal barrier function in severe malnutrition
por: Ling, Catriona, et al.
Publicado: (2023)

Upregulation of Salmonella-Induced IL-6 Production in Caco-2 Cells by PJ-34, PARP-1 Inhibitor: Involvement of PI3K, p38 MAPK, ERK, JNK, and NF-κB
por: Huang, Fu-Chen
Publicado: (2009)

PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer
por: Curtin, Nicola, et al.
Publicado: (2020)

CD38-NAD(+)-Sirt1 axis in T cell immunotherapy
por: Chatterjee, Shilpak, et al.
Publicado: (2019)

NAD(+), Sirtuins and PARPs: enhancing oocyte developmental competence
por: POLLARD, Charley-Lea, et al.
Publicado: (2022)

SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
por: Luna, Augustin, et al.
Publicado: (2013)

The Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitor PJ34 Reduces Pulmonary Ischemia-Reperfusion Injury in Rats
por: Hatachi, Go, et al.
Publicado: (2014)

763 The Cardioprotective Effects of Sildenafil, PJ34, MitoTEMPO, and ZLN005 in the Early After Burn Injury
por: Radhakrishnan, Ravi, et al.
Publicado: (2023)

Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease
por: Tovar-Palacio, Claudia, et al.
Publicado: (2022)

MeCP2 inhibits cell functionality through FoxO3a and autophagy in endothelial progenitor cells
por: Zha, Siyuan, et al.
Publicado: (2019)

The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
por: Guo, Xiumei, et al.
Publicado: (2012)

NAD-Glycohydrolase Depletes Intracellular NAD(+) and Inhibits Acidification of Autophagosomes to Enhance Multiplication of Group A Streptococcus in Endothelial Cells
por: Hsieh, Cheng-Lu, et al.
Publicado: (2018)

Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids
por: Lee, Jong-Hyuk, et al.
Publicado: (2022)

Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain
por: Bonnin, Philippe, et al.
Publicado: (2021)

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD(+)/SIRT6 axis
por: Koczor, Christopher A., et al.
Publicado: (2021)

SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity
por: Feng, Xiaojun, et al.
Publicado: (2020)

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD(+)-Sirt1 pathway
por: Pi, Chenchen, et al.
Publicado: (2021)

Deacetylation-dependent regulation of PARP1 by SIRT2 dictates ubiquitination of PARP1 in oxidative stress-induced vascular injury
por: Zhang, Naijin, et al.
Publicado: (2021)

The Role of NAD+, SIRTs Interactions in Stimulating and Counteracting Carcinogenesis
por: Podyacheva, Ekaterina, et al.
Publicado: (2023)

Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD(+) and SIRT1
por: Ghosh, Nandini, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_edssisibhd5s7oiddtqe37gsac