Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury

Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical tria...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Lingfei, Hu, Chenxia, Zhang, Ping, Jiang, Hua, Chen, Jianghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108125/
https://www.ncbi.nlm.nih.gov/pubmed/30139368
http://dx.doi.org/10.1186/s13287-018-0973-3
_version_ 1783350090310615040
author Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
author_facet Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
author_sort Zhao, Lingfei
collection PubMed
description Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical trials show confusing results (NCT00733876, NCT01602328). One primary cause of the limited therapeutic effect may result from poor engraftment of transplanted cells. To solve this problem, investigators have developed a series of preconditioning strategies to improve MSC engraftment in animal AKI models. In this review, we summarize these previous studies, providing an integrated and updated view of different preconditioning strategies aimed at promoting the therapeutic effect of MSCs in AKI patients.
format Online
Article
Text
id pubmed-6108125
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61081252018-08-28 Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury Zhao, Lingfei Hu, Chenxia Zhang, Ping Jiang, Hua Chen, Jianghua Stem Cell Res Ther Review Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (MSC) research make MSCs a promising candidate for AKI management but relevant clinical trials show confusing results (NCT00733876, NCT01602328). One primary cause of the limited therapeutic effect may result from poor engraftment of transplanted cells. To solve this problem, investigators have developed a series of preconditioning strategies to improve MSC engraftment in animal AKI models. In this review, we summarize these previous studies, providing an integrated and updated view of different preconditioning strategies aimed at promoting the therapeutic effect of MSCs in AKI patients. BioMed Central 2018-08-23 /pmc/articles/PMC6108125/ /pubmed/30139368 http://dx.doi.org/10.1186/s13287-018-0973-3 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhao, Lingfei
Hu, Chenxia
Zhang, Ping
Jiang, Hua
Chen, Jianghua
Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title_full Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title_fullStr Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title_full_unstemmed Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title_short Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
title_sort novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108125/
https://www.ncbi.nlm.nih.gov/pubmed/30139368
http://dx.doi.org/10.1186/s13287-018-0973-3
work_keys_str_mv AT zhaolingfei novelpreconditioningstrategiesforenhancingthemigratoryabilityofmesenchymalstemcellsinacutekidneyinjury
AT huchenxia novelpreconditioningstrategiesforenhancingthemigratoryabilityofmesenchymalstemcellsinacutekidneyinjury
AT zhangping novelpreconditioningstrategiesforenhancingthemigratoryabilityofmesenchymalstemcellsinacutekidneyinjury
AT jianghua novelpreconditioningstrategiesforenhancingthemigratoryabilityofmesenchymalstemcellsinacutekidneyinjury
AT chenjianghua novelpreconditioningstrategiesforenhancingthemigratoryabilityofmesenchymalstemcellsinacutekidneyinjury

Ejemplares similares