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Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage
BACKGROUND: Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108148/ https://www.ncbi.nlm.nih.gov/pubmed/30143058 http://dx.doi.org/10.1186/s12905-018-0618-9 |
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author | Husseini-Akram, Frida Haroun, Sally Altmäe, Signe Skjöldebrand-Sparre, Lottie Åkerud, Helena Poromaa, Inger Sundström Landgren, Britt-Marie Stavreus-Evers, Anneli |
author_facet | Husseini-Akram, Frida Haroun, Sally Altmäe, Signe Skjöldebrand-Sparre, Lottie Åkerud, Helena Poromaa, Inger Sundström Landgren, Britt-Marie Stavreus-Evers, Anneli |
author_sort | Husseini-Akram, Frida |
collection | PubMed |
description | BACKGROUND: Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women. METHODS: This study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied. RESULTS: Polymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001). CONCLUSIONS: Variations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12905-018-0618-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6108148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61081482018-08-28 Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage Husseini-Akram, Frida Haroun, Sally Altmäe, Signe Skjöldebrand-Sparre, Lottie Åkerud, Helena Poromaa, Inger Sundström Landgren, Britt-Marie Stavreus-Evers, Anneli BMC Womens Health Research Article BACKGROUND: Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women. METHODS: This study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied. RESULTS: Polymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001). CONCLUSIONS: Variations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12905-018-0618-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-24 /pmc/articles/PMC6108148/ /pubmed/30143058 http://dx.doi.org/10.1186/s12905-018-0618-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Husseini-Akram, Frida Haroun, Sally Altmäe, Signe Skjöldebrand-Sparre, Lottie Åkerud, Helena Poromaa, Inger Sundström Landgren, Britt-Marie Stavreus-Evers, Anneli Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title | Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title_full | Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title_fullStr | Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title_full_unstemmed | Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title_short | Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage |
title_sort | hyaluronan–binding protein 2 (habp2) gene variation in women with recurrent miscarriage |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108148/ https://www.ncbi.nlm.nih.gov/pubmed/30143058 http://dx.doi.org/10.1186/s12905-018-0618-9 |
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