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Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

Apolipoprotein E4 (ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan (i.e., olde...

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Autor principal: Piers, Ryan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108197/
https://www.ncbi.nlm.nih.gov/pubmed/30106031
http://dx.doi.org/10.4103/1673-5374.235408
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author Piers, Ryan J.
author_facet Piers, Ryan J.
author_sort Piers, Ryan J.
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description Apolipoprotein E4 (ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan (i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates). Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer's disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.
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spelling pubmed-61081972018-09-05 Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan Piers, Ryan J. Neural Regen Res Review Apolipoprotein E4 (ApoE4) is a prominent genetic risk factor for Alzheimer's disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan (i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates). Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer's disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele. Medknow Publications & Media Pvt Ltd 2018-08 /pmc/articles/PMC6108197/ /pubmed/30106031 http://dx.doi.org/10.4103/1673-5374.235408 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Piers, Ryan J.
Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title_full Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title_fullStr Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title_full_unstemmed Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title_short Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
title_sort structural brain volume differences between cognitively intact apoe4 carriers and non-carriers across the lifespan
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108197/
https://www.ncbi.nlm.nih.gov/pubmed/30106031
http://dx.doi.org/10.4103/1673-5374.235408
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