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Amnion epithelial cells – a novel therapy for ischemic stroke?
Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenes...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108203/ https://www.ncbi.nlm.nih.gov/pubmed/30106038 http://dx.doi.org/10.4103/1673-5374.235223 |
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author | Evans, Megan A. Broughton, Brad R.S. Drummond, Grant R. Ma, Henry Phan, Thanh G. Wallace, Euan M. Lim, Rebecca Sobey, Christopher G. |
author_facet | Evans, Megan A. Broughton, Brad R.S. Drummond, Grant R. Ma, Henry Phan, Thanh G. Wallace, Euan M. Lim, Rebecca Sobey, Christopher G. |
author_sort | Evans, Megan A. |
collection | PubMed |
description | Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells (hAECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days post-stroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that hAECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy. |
format | Online Article Text |
id | pubmed-6108203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61082032018-09-05 Amnion epithelial cells – a novel therapy for ischemic stroke? Evans, Megan A. Broughton, Brad R.S. Drummond, Grant R. Ma, Henry Phan, Thanh G. Wallace, Euan M. Lim, Rebecca Sobey, Christopher G. Neural Regen Res Review Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells (hAECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days post-stroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that hAECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy. Medknow Publications & Media Pvt Ltd 2018-08 /pmc/articles/PMC6108203/ /pubmed/30106038 http://dx.doi.org/10.4103/1673-5374.235223 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Evans, Megan A. Broughton, Brad R.S. Drummond, Grant R. Ma, Henry Phan, Thanh G. Wallace, Euan M. Lim, Rebecca Sobey, Christopher G. Amnion epithelial cells – a novel therapy for ischemic stroke? |
title | Amnion epithelial cells – a novel therapy for ischemic stroke? |
title_full | Amnion epithelial cells – a novel therapy for ischemic stroke? |
title_fullStr | Amnion epithelial cells – a novel therapy for ischemic stroke? |
title_full_unstemmed | Amnion epithelial cells – a novel therapy for ischemic stroke? |
title_short | Amnion epithelial cells – a novel therapy for ischemic stroke? |
title_sort | amnion epithelial cells – a novel therapy for ischemic stroke? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108203/ https://www.ncbi.nlm.nih.gov/pubmed/30106038 http://dx.doi.org/10.4103/1673-5374.235223 |
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