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Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury
The mitochondrion serves many functions in the central nervous system (CNS) and other organs beyond the well-recognized role of adenosine triphosphate (ATP) production. This includes calcium-dependent cell signaling, regulation of gene expression, synthesis and release of cytotoxic reactive oxygen s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108215/ https://www.ncbi.nlm.nih.gov/pubmed/30106036 http://dx.doi.org/10.4103/1673-5374.235218 |
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author | Springer, Joe E. Prajapati, Pareshkumar Sullivan, Patrick G. |
author_facet | Springer, Joe E. Prajapati, Pareshkumar Sullivan, Patrick G. |
author_sort | Springer, Joe E. |
collection | PubMed |
description | The mitochondrion serves many functions in the central nervous system (CNS) and other organs beyond the well-recognized role of adenosine triphosphate (ATP) production. This includes calcium-dependent cell signaling, regulation of gene expression, synthesis and release of cytotoxic reactive oxygen species, and the release of cytochrome c and other apoptotic cell death factors. Traumatic injury to the CNS results in a rapid and, in some cases, sustained loss of mitochondrial function. One consequence of compromised mitochondrial function is induction of the mitochondrial permeability transition (mPT) state due to formation of the cyclosporine A sensitive permeability transition pore (mPTP). In this mini-review, we summarize evidence supporting the involvement of the mPTP as a mediator of mitochondrial and cellular demise following CNS traumatic injury and discuss the beneficial effects and limitations of the current ex-perimental strategies targeting the mPTP. |
format | Online Article Text |
id | pubmed-6108215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61082152018-09-05 Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury Springer, Joe E. Prajapati, Pareshkumar Sullivan, Patrick G. Neural Regen Res Review The mitochondrion serves many functions in the central nervous system (CNS) and other organs beyond the well-recognized role of adenosine triphosphate (ATP) production. This includes calcium-dependent cell signaling, regulation of gene expression, synthesis and release of cytotoxic reactive oxygen species, and the release of cytochrome c and other apoptotic cell death factors. Traumatic injury to the CNS results in a rapid and, in some cases, sustained loss of mitochondrial function. One consequence of compromised mitochondrial function is induction of the mitochondrial permeability transition (mPT) state due to formation of the cyclosporine A sensitive permeability transition pore (mPTP). In this mini-review, we summarize evidence supporting the involvement of the mPTP as a mediator of mitochondrial and cellular demise following CNS traumatic injury and discuss the beneficial effects and limitations of the current ex-perimental strategies targeting the mPTP. Medknow Publications & Media Pvt Ltd 2018-08 /pmc/articles/PMC6108215/ /pubmed/30106036 http://dx.doi.org/10.4103/1673-5374.235218 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Springer, Joe E. Prajapati, Pareshkumar Sullivan, Patrick G. Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title | Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title_full | Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title_fullStr | Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title_full_unstemmed | Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title_short | Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
title_sort | targeting the mitochondrial permeability transition pore in traumatic central nervous system injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108215/ https://www.ncbi.nlm.nih.gov/pubmed/30106036 http://dx.doi.org/10.4103/1673-5374.235218 |
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