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Risk factors for deep vein thrombosis of lower extremities in Sudanese women

AIM: In this study, we aimed to analyze the genetic and acquired risk factors for deep vein thrombosis (DVT) of the lower extremities among Sudanese women. METHODS: A total of 136 women were enrolled in the study, including 75 DVT patients and 61 healthy controls. Demographic and clinical data were...

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Autores principales: Ibrahim, Nadir Ahmed, Hassan, Fathelrahman M, Elgari, Mahmoud Mohamed, Abdalla, Sana Eltahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108343/
https://www.ncbi.nlm.nih.gov/pubmed/30154662
http://dx.doi.org/10.2147/VHRM.S170556
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author Ibrahim, Nadir Ahmed
Hassan, Fathelrahman M
Elgari, Mahmoud Mohamed
Abdalla, Sana Eltahir
author_facet Ibrahim, Nadir Ahmed
Hassan, Fathelrahman M
Elgari, Mahmoud Mohamed
Abdalla, Sana Eltahir
author_sort Ibrahim, Nadir Ahmed
collection PubMed
description AIM: In this study, we aimed to analyze the genetic and acquired risk factors for deep vein thrombosis (DVT) of the lower extremities among Sudanese women. METHODS: A total of 136 women were enrolled in the study, including 75 DVT patients and 61 healthy controls. Demographic and clinical data were collected using a specific questionnaire. Citrated blood samples of patients and controls were used for coagulation assays, and DNAs isolated from EDTA-blood samples were used for the detection of Factor V Leiden and prothrombin G20210A mutations using multiplex polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS: Both gene mutations were found to be absent from all 136 subjects, and therefore did not account for the incidence of DVT in Sudanese women. Of the 75 DVTs, 70 (93.3%) were localized in the left leg and 5 (6.7%) in the right leg. Additionally, 84% of the DVTs were proximal and 16% were distal. Among the 75 patients, 22 (29.33%) were postpartum, 7 (9.33%) were pregnant, and 46 (61.33%) were nonpregnant. Levels of prothrombin fragment 1+2, prothrombin time, activated partial thromboplastin time, and D-dimer were significantly higher in DVT patients than in healthy controls (P<0.0001). CONCLUSION: Risk factors that most significantly affected patients in the 18–45 years age group were pregnancy and oral contraceptive usage, whereas those that most significantly affected patients in the 66–90 years age group were immobility, heart disease, and history of DVT.
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spelling pubmed-61083432018-08-28 Risk factors for deep vein thrombosis of lower extremities in Sudanese women Ibrahim, Nadir Ahmed Hassan, Fathelrahman M Elgari, Mahmoud Mohamed Abdalla, Sana Eltahir Vasc Health Risk Manag Original Research AIM: In this study, we aimed to analyze the genetic and acquired risk factors for deep vein thrombosis (DVT) of the lower extremities among Sudanese women. METHODS: A total of 136 women were enrolled in the study, including 75 DVT patients and 61 healthy controls. Demographic and clinical data were collected using a specific questionnaire. Citrated blood samples of patients and controls were used for coagulation assays, and DNAs isolated from EDTA-blood samples were used for the detection of Factor V Leiden and prothrombin G20210A mutations using multiplex polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS: Both gene mutations were found to be absent from all 136 subjects, and therefore did not account for the incidence of DVT in Sudanese women. Of the 75 DVTs, 70 (93.3%) were localized in the left leg and 5 (6.7%) in the right leg. Additionally, 84% of the DVTs were proximal and 16% were distal. Among the 75 patients, 22 (29.33%) were postpartum, 7 (9.33%) were pregnant, and 46 (61.33%) were nonpregnant. Levels of prothrombin fragment 1+2, prothrombin time, activated partial thromboplastin time, and D-dimer were significantly higher in DVT patients than in healthy controls (P<0.0001). CONCLUSION: Risk factors that most significantly affected patients in the 18–45 years age group were pregnancy and oral contraceptive usage, whereas those that most significantly affected patients in the 66–90 years age group were immobility, heart disease, and history of DVT. Dove Medical Press 2018-08-20 /pmc/articles/PMC6108343/ /pubmed/30154662 http://dx.doi.org/10.2147/VHRM.S170556 Text en © 2018 Ibrahim et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ibrahim, Nadir Ahmed
Hassan, Fathelrahman M
Elgari, Mahmoud Mohamed
Abdalla, Sana Eltahir
Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title_full Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title_fullStr Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title_full_unstemmed Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title_short Risk factors for deep vein thrombosis of lower extremities in Sudanese women
title_sort risk factors for deep vein thrombosis of lower extremities in sudanese women
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108343/
https://www.ncbi.nlm.nih.gov/pubmed/30154662
http://dx.doi.org/10.2147/VHRM.S170556
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