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Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer

INTRODUCTION: Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or “flare” in thymidine salvage pathway activity at 2 hrs. of therapy which can be measurable with FLT-PET ([18F]fluorothymidine-positron emission tomography) in...

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Detalles Bibliográficos
Autores principales:	Chen, Xiao, Yang, Yizeng, Katz, Sharyn I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108460/ https://www.ncbi.nlm.nih.gov/pubmed/30142195 http://dx.doi.org/10.1371/journal.pone.0202384

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