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Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation

PURPOSE: To investigate reproducible surgical techniques to optimize the long-term safety of liquid crystal polymer (LCP)-based retinal prosthesis implantation. METHODS: An LCP-based retinal prosthesis is fabricated monolithically on a single-body LCP substrate with all components, including the pac...

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Autores principales: Bae, So Hyun, Jeong, Joonsoo, Kim, Sung June, Chung, Hum, Seo, Jong-Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108533/
https://www.ncbi.nlm.nih.gov/pubmed/30159210
http://dx.doi.org/10.1167/tvst.7.4.17
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author Bae, So Hyun
Jeong, Joonsoo
Kim, Sung June
Chung, Hum
Seo, Jong-Mo
author_facet Bae, So Hyun
Jeong, Joonsoo
Kim, Sung June
Chung, Hum
Seo, Jong-Mo
author_sort Bae, So Hyun
collection PubMed
description PURPOSE: To investigate reproducible surgical techniques to optimize the long-term safety of liquid crystal polymer (LCP)-based retinal prosthesis implantation. METHODS: An LCP-based retinal prosthesis is fabricated monolithically on a single-body LCP substrate with all components, including the package and electrode array. We implanted the electrode array into the suprachoroidal space and anchored the package and transition part to the sclera in rabbits (n = 11). The safety profile was assessed upon the completion of the surgery and postoperatively. RESULTS: The surgical procedures for implantation of the entire system were easily performed in nine eyes (81.8%) without any intraoperative complications. In the other two eyes (18.2%), surgical complications related to electrode insertion, including optic nerve damage and retinal tear, arose. In 10 eyes (90.9%), the devices were well tolerated for at least 3 months. However, in most eyes (nine; 81.8%), two complications began to appear after 3 months, postoperatively, including conjunctival erosion or dehiscence over the package or transition part. The electrode arrays were maintained safely in the suprachoroidal space after surgery without any complications, regardless of the status of the extraocular components in all cases except two intraoperative complications. CONCLUSIONS: We established safe and reproducible surgical techniques for implantation of our LCP-based retinal prosthesis into the suprachoroidal space. Although issues related to surgical technique or device configuration were identified, further technical solutions would improve the long-term safety of device implantation. TRANSLATIONAL RELEVANCE: This study presents successful implantation of LCP-based retinal prosthesis. The technical solutions will permit an optimization of surgical techniques.
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spelling pubmed-61085332018-08-29 Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation Bae, So Hyun Jeong, Joonsoo Kim, Sung June Chung, Hum Seo, Jong-Mo Transl Vis Sci Technol Articles PURPOSE: To investigate reproducible surgical techniques to optimize the long-term safety of liquid crystal polymer (LCP)-based retinal prosthesis implantation. METHODS: An LCP-based retinal prosthesis is fabricated monolithically on a single-body LCP substrate with all components, including the package and electrode array. We implanted the electrode array into the suprachoroidal space and anchored the package and transition part to the sclera in rabbits (n = 11). The safety profile was assessed upon the completion of the surgery and postoperatively. RESULTS: The surgical procedures for implantation of the entire system were easily performed in nine eyes (81.8%) without any intraoperative complications. In the other two eyes (18.2%), surgical complications related to electrode insertion, including optic nerve damage and retinal tear, arose. In 10 eyes (90.9%), the devices were well tolerated for at least 3 months. However, in most eyes (nine; 81.8%), two complications began to appear after 3 months, postoperatively, including conjunctival erosion or dehiscence over the package or transition part. The electrode arrays were maintained safely in the suprachoroidal space after surgery without any complications, regardless of the status of the extraocular components in all cases except two intraoperative complications. CONCLUSIONS: We established safe and reproducible surgical techniques for implantation of our LCP-based retinal prosthesis into the suprachoroidal space. Although issues related to surgical technique or device configuration were identified, further technical solutions would improve the long-term safety of device implantation. TRANSLATIONAL RELEVANCE: This study presents successful implantation of LCP-based retinal prosthesis. The technical solutions will permit an optimization of surgical techniques. The Association for Research in Vision and Ophthalmology 2018-08-24 /pmc/articles/PMC6108533/ /pubmed/30159210 http://dx.doi.org/10.1167/tvst.7.4.17 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Bae, So Hyun
Jeong, Joonsoo
Kim, Sung June
Chung, Hum
Seo, Jong-Mo
Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title_full Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title_fullStr Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title_full_unstemmed Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title_short Investigation of Surgical Techniques for Optimization of Long-Term Outcomes of LCP-Based Retinal Prosthesis Implantation
title_sort investigation of surgical techniques for optimization of long-term outcomes of lcp-based retinal prosthesis implantation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108533/
https://www.ncbi.nlm.nih.gov/pubmed/30159210
http://dx.doi.org/10.1167/tvst.7.4.17
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