Cargando…

Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions

[Image: see text] By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Dongfei, Lipponen, Katriina, Quan, Peng, Wan, Xiaocao, Zhang, Hongbo, Mäkilä, Ermei, Salonen, Jarno, Kostiainen, Risto, Hirvonen, Jouni, Kotiaho, Tapio, Santos, Hélder A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108535/
https://www.ncbi.nlm.nih.gov/pubmed/30159385
http://dx.doi.org/10.1021/acsbiomaterials.8b00343
_version_ 1783350163421528064
author Liu, Dongfei
Lipponen, Katriina
Quan, Peng
Wan, Xiaocao
Zhang, Hongbo
Mäkilä, Ermei
Salonen, Jarno
Kostiainen, Risto
Hirvonen, Jouni
Kotiaho, Tapio
Santos, Hélder A.
author_facet Liu, Dongfei
Lipponen, Katriina
Quan, Peng
Wan, Xiaocao
Zhang, Hongbo
Mäkilä, Ermei
Salonen, Jarno
Kostiainen, Risto
Hirvonen, Jouni
Kotiaho, Tapio
Santos, Hélder A.
author_sort Liu, Dongfei
collection PubMed
description [Image: see text] By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi. Among four PSi particles, TOPSi with hydrophilic surface and smaller pore size showed the weakest adsorption toward phosphatidylcholines. By increasing the pore size from roughly 12.5 to 18.0 nm (TOPSi vs AnnTOPSi), the quantity of phosphatidylcholines adsorbed by TOPSi was enhanced to the same level of hydrophilic APTES-TCPSi and hydrophobic THCPSi. The 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors.
format Online
Article
Text
id pubmed-6108535
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-61085352018-08-27 Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions Liu, Dongfei Lipponen, Katriina Quan, Peng Wan, Xiaocao Zhang, Hongbo Mäkilä, Ermei Salonen, Jarno Kostiainen, Risto Hirvonen, Jouni Kotiaho, Tapio Santos, Hélder A. ACS Biomater Sci Eng [Image: see text] By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi. Among four PSi particles, TOPSi with hydrophilic surface and smaller pore size showed the weakest adsorption toward phosphatidylcholines. By increasing the pore size from roughly 12.5 to 18.0 nm (TOPSi vs AnnTOPSi), the quantity of phosphatidylcholines adsorbed by TOPSi was enhanced to the same level of hydrophilic APTES-TCPSi and hydrophobic THCPSi. The 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors. American Chemical Society 2018-06-14 2018-07-09 /pmc/articles/PMC6108535/ /pubmed/30159385 http://dx.doi.org/10.1021/acsbiomaterials.8b00343 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Liu, Dongfei
Lipponen, Katriina
Quan, Peng
Wan, Xiaocao
Zhang, Hongbo
Mäkilä, Ermei
Salonen, Jarno
Kostiainen, Risto
Hirvonen, Jouni
Kotiaho, Tapio
Santos, Hélder A.
Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title_full Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title_fullStr Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title_full_unstemmed Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title_short Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
title_sort impact of pore size and surface chemistry of porous silicon particles and structure of phospholipids on their interactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108535/
https://www.ncbi.nlm.nih.gov/pubmed/30159385
http://dx.doi.org/10.1021/acsbiomaterials.8b00343
work_keys_str_mv AT liudongfei impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT lipponenkatriina impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT quanpeng impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT wanxiaocao impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT zhanghongbo impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT makilaermei impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT salonenjarno impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT kostiainenristo impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT hirvonenjouni impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT kotiahotapio impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions
AT santosheldera impactofporesizeandsurfacechemistryofporoussiliconparticlesandstructureofphospholipidsontheirinteractions