A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl. While chemical methylat...

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Detalles Bibliográficos
Autores principales: Song, Haigang, van der Velden, Niels S., Shiran, Sally L., Bleiziffer, Patrick, Zach, Christina, Sieber, Ramon, Imani, Aman S., Krausbeck, Florian, Aebi, Markus, Freeman, Michael F., Riniker, Sereina, Künzler, Markus, Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108569/
https://www.ncbi.nlm.nih.gov/pubmed/30151425
http://dx.doi.org/10.1126/sciadv.aat2720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108569/
https://www.ncbi.nlm.nih.gov/pubmed/30151425
http://dx.doi.org/10.1126/sciadv.aat2720

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