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Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“

BACKGROUND: Keratinocyte cancers are malignant diseases with a broad incidence of spread which tends to increase during the last couple of decades. The solar radiation plays a dominant role in the occurrence of BCC, but certain genetic phenotypes appear to be risky from an etiological point of view....

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Autores principales: Temelkova, Ivanka, Mangarov, Hristo, Tronnier, Michael, Terziev, Ivan, Tchernev, Georgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108802/
https://www.ncbi.nlm.nih.gov/pubmed/30159071
http://dx.doi.org/10.3889/oamjms.2018.203
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author Temelkova, Ivanka
Mangarov, Hristo
Tronnier, Michael
Terziev, Ivan
Tchernev, Georgi
author_facet Temelkova, Ivanka
Mangarov, Hristo
Tronnier, Michael
Terziev, Ivan
Tchernev, Georgi
author_sort Temelkova, Ivanka
collection PubMed
description BACKGROUND: Keratinocyte cancers are malignant diseases with a broad incidence of spread which tends to increase during the last couple of decades. The solar radiation plays a dominant role in the occurrence of BCC, but certain genetic phenotypes appear to be risky from an etiological point of view. Metatypical basal cell carcinoma (MTBCC) is a rare variant of BCC which combines the clinical and histological characteristics of BCC and SCC. Clinically they are indistinguishable from the conventional BCC, and only the histological examination can differentiate them. The MTBCC is a histological subtype which is considered more aggressive due to its ability to produce local recurrences or distant metastases. CASE REPORT: We present a 44-year old patient with multiple BCCs disseminated on the face and body. The biopsy established mixed type histology: three metatypical and four solid BCCs. The lesions were removed via elliptical excision with a field of operational security of 0.5 cm in all directions. CONCLUSIONS: The eruptive (multiple) BCCs are a challenge about the choice of a therapy option. This is because clinically completely identical tumours show different histopathological characteristics, namely those with a tendency to metastasise. Having in mind one of the hypotheses of metatypical BCC emergence - the improper or inadequate radiotherapy (as a choice of therapy) could trigger the transition of a conventional tumour to a metastasising one, the surgical treatment appears to be the most secure treatment method.
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spelling pubmed-61088022018-08-29 Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“ Temelkova, Ivanka Mangarov, Hristo Tronnier, Michael Terziev, Ivan Tchernev, Georgi Open Access Maced J Med Sci Case Report BACKGROUND: Keratinocyte cancers are malignant diseases with a broad incidence of spread which tends to increase during the last couple of decades. The solar radiation plays a dominant role in the occurrence of BCC, but certain genetic phenotypes appear to be risky from an etiological point of view. Metatypical basal cell carcinoma (MTBCC) is a rare variant of BCC which combines the clinical and histological characteristics of BCC and SCC. Clinically they are indistinguishable from the conventional BCC, and only the histological examination can differentiate them. The MTBCC is a histological subtype which is considered more aggressive due to its ability to produce local recurrences or distant metastases. CASE REPORT: We present a 44-year old patient with multiple BCCs disseminated on the face and body. The biopsy established mixed type histology: three metatypical and four solid BCCs. The lesions were removed via elliptical excision with a field of operational security of 0.5 cm in all directions. CONCLUSIONS: The eruptive (multiple) BCCs are a challenge about the choice of a therapy option. This is because clinically completely identical tumours show different histopathological characteristics, namely those with a tendency to metastasise. Having in mind one of the hypotheses of metatypical BCC emergence - the improper or inadequate radiotherapy (as a choice of therapy) could trigger the transition of a conventional tumour to a metastasising one, the surgical treatment appears to be the most secure treatment method. Republic of Macedonia 2018-07-30 /pmc/articles/PMC6108802/ /pubmed/30159071 http://dx.doi.org/10.3889/oamjms.2018.203 Text en Copyright: © 2018 Ivanka Temelkova, Hristo Mangarov, Michael Tronnier, Ivan Terziev, Georgi Tchernev http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Case Report
Temelkova, Ivanka
Mangarov, Hristo
Tronnier, Michael
Terziev, Ivan
Tchernev, Georgi
Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title_full Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title_fullStr Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title_full_unstemmed Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title_short Eruptive Basaliomas: “Why we have to Perform Surgery?” Or Said Otherwise: “Catch The Metatypical!“
title_sort eruptive basaliomas: “why we have to perform surgery?” or said otherwise: “catch the metatypical!“
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108802/
https://www.ncbi.nlm.nih.gov/pubmed/30159071
http://dx.doi.org/10.3889/oamjms.2018.203
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