SIRT6 haploinsufficiency induces BRAF(V600E) melanoma cell resistance to MAPK inhibitors via IGF signalling

While multiple mechanisms of BRAF(V600)-mutant melanoma resistance to targeted MAPK signaling inhibitors (MAPKi) have been reported, the epigenetic regulation of this process remains undetermined. Here, using a CRISPR–Cas9 screen targeting chromatin regulators, we discover that haploinsufficiency of...

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Detalles Bibliográficos
Autores principales: Strub, Thomas, Ghiraldini, Flavia G., Carcamo, Saul, Li, Man, Wroblewska, Aleksandra, Singh, Rajendra, Goldberg, Matthew S., Hasson, Dan, Wang, Zichen, Gallagher, Stuart J., Hersey, Peter, Ma’ayan, Avi, Long, Georgina V., Scolyer, Richard A., Brown, Brian, Zheng, Bin, Bernstein, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109055/
https://www.ncbi.nlm.nih.gov/pubmed/30143629
http://dx.doi.org/10.1038/s41467-018-05966-z

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