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Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations

In a one-way cross-over study, we investigated the effect of Khat, a natural amphetamine-like psychostimulant plant, on catalytic activities of five major drug-metabolizing cytochrome P450 (CYP) enzymes. After a one-week Khat abstinence, 63 Ethiopian male volunteers were phenotyped using cocktail pr...

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Detalles Bibliográficos
Autores principales:	Bedada, Worku, de Andrés, Fernando, Engidawork, Ephrem, Hussein, Jemal, LLerena, Adrián, Aklillu, Eleni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109098/ https://www.ncbi.nlm.nih.gov/pubmed/30143732 http://dx.doi.org/10.1038/s41598-018-31191-1

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