Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

Neural tube defects (NTDs) are serious congenital malformations. Excessive maternal homocysteine (Hcy) increases the risk of NTDs, while its mechanism remains elusive. Here we report the role of histone homocysteinylation in neural tube closure (NTC). A total of 39 histone homocysteinylation sites a...

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Detalles Bibliográficos
Autores principales: Zhang, Qin, Bai, Baoling, Mei, Xinyu, Wan, Chunlei, Cao, Haiyan, Dan Li, Wang, Shan, Zhang, Min, Wang, Zhigang, Wu, Jianxin, Wang, Hongyan, Huo, Junsheng, Ding, Gangqiang, Zhao, Jianyuan, Xie, Qiu, Wang, Li, Qiu, Zhiyong, Zhao, Shiming, Zhang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109101/
https://www.ncbi.nlm.nih.gov/pubmed/30143612
http://dx.doi.org/10.1038/s41467-018-05451-7

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