p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide (AgRP), but not proopiomelanocortin (POMC) or steroidogenic factor-1 (SF1)...

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Detalles Bibliográficos
Autores principales: Quiñones, Mar, Al-Massadi, Omar, Folgueira, Cintia, Bremser, Stephan, Gallego, Rosalía, Torres-Leal, Leonardo, Haddad-Tóvolli, Roberta, García-Caceres, Cristina, Hernandez-Bautista, Rene, Lam, Brian Y. H., Beiroa, Daniel, Sanchez-Rebordelo, Estrella, Senra, Ana, Malagon, Jose A., Valerio, Patricia, Fondevila, Marcos F., Fernø, Johan, Malagon, Maria M., Contreras, Raian, Pfluger, Paul, Brüning, Jens C., Yeo, Giles, Tschöp, Matthias, Diéguez, Carlos, López, Miguel, Claret, Marc, Kloppenburg, Peter, Sabio, Guadalupe, Nogueiras, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109113/
https://www.ncbi.nlm.nih.gov/pubmed/30143607
http://dx.doi.org/10.1038/s41467-018-05711-6

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