NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in DMD patients, the mechanisms underlying heart failure are not well understood. Previously, we showed that NF-κB exacerbates DMD skeletal musc...

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Detalles Bibliográficos
Autores principales: Peterson, Jennifer M., Wang, David J., Shettigar, Vikram, Roof, Steve R., Canan, Benjamin D., Bakkar, Nadine, Shintaku, Jonathan, Gu, Jin-Mo, Little, Sean C., Ratnam, Nivedita M., Londhe, Priya, Lu, Leina, Gaw, Christopher E., Petrosino, Jennifer M., Liyanarachchi, Sandya, Wang, Huating, Janssen, Paul M. L., Davis, Jonathan P., Ziolo, Mark T., Sharma, Sudarshana M., Guttridge, Denis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109146/
https://www.ncbi.nlm.nih.gov/pubmed/30143619
http://dx.doi.org/10.1038/s41467-018-05910-1

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