Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes

Secreted Wnts play crucial roles in synaptogenesis and synapse maintenance, but endogenous factors promoting synapse elimination in central neurons remain unknown. Here we show that proline-rich 7 (PRR7) induces specific removal of excitatory synapses and acts as a Wnt inhibitor. Remarkably, transme...

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Detalles Bibliográficos
Autores principales: Lee, Sang H., Shin, Seung Min, Zhong, Peng, Kim, Hyun-Taek, Kim, Dong-Il, Kim, June Myoung, Do Heo, Won, Kim, Dae-Won, Yeo, Chang-Yeol, Kim, Cheol-Hee, Liu, Qing-song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109165/
https://www.ncbi.nlm.nih.gov/pubmed/30143647
http://dx.doi.org/10.1038/s41467-018-05858-2

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