The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits cristae remodeling, protects from mitochondrial dysfunction. Here we identify the mitochondrial F(1)F(o)-ATP synthase as the effector of OPA1 in mitochondrial protection. In OPA1 overexpressing cells, the loss...

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Detalles Bibliográficos
Autores principales: Quintana-Cabrera, Rubén, Quirin, Charlotte, Glytsou, Christina, Corrado, Mauro, Urbani, Andrea, Pellattiero, Anna, Calvo, Enrique, Vázquez, Jesús, Enríquez, José Antonio, Gerle, Christoph, Soriano, María Eugenia, Bernardi, Paolo, Scorrano, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109181/
https://www.ncbi.nlm.nih.gov/pubmed/30143614
http://dx.doi.org/10.1038/s41467-018-05655-x

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