Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

Bone morphogenetic protein (BMP) signaling is essential for osteogenesis. However, recombinant human BMPs (rhBMPs) exhibit large inter-individual variations in local bone formation during clinical spinal fusion. Smurf1 ubiquitinates BMP downstream molecules for degradation. Here, we classify age-rel...

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Detalles Bibliográficos
Autores principales: Liang, Chao, Peng, Songlin, Li, Jie, Lu, Jun, Guan, Daogang, Jiang, Feng, Lu, Cheng, Li, Fangfei, He, Xiaojuan, Zhu, Hailong, Au, D. W. T., Yang, Dazhi, Zhang, Bao-Ting, Lu, Aiping, Zhang, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109183/
https://www.ncbi.nlm.nih.gov/pubmed/30143635
http://dx.doi.org/10.1038/s41467-018-05974-z

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