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Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung

INTRODUCTION: Loss of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to upregulation of the epithelial sodium channel (ENaC). Thickened mucus and depleted airway surface liquid (ASL) then lead to impair...

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Detalles Bibliográficos
Autores principales:	Tagalakis, Aristides D, Munye, Mustafa M, Ivanova, Rositsa, Chen, Hanpeng, Smith, Claire M, Aldossary, Ahmad M, Rosa, Luca Z, Moulding, Dale, Barnes, Josephine L, Kafetzis, Konstantinos N, Jones, Stuart A, Baines, Deborah L, Moss, Guy W J, O’Callaghan, Christopher, McAnulty, Robin J, Hart, Stephen L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Cystic Fibrosis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109249/ https://www.ncbi.nlm.nih.gov/pubmed/29748250 http://dx.doi.org/10.1136/thoraxjnl-2017-210670

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