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Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM)...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109274/ https://www.ncbi.nlm.nih.gov/pubmed/29760169 http://dx.doi.org/10.1136/gutjnl-2018-315988 |
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author | Wang, Jinfeng Zheng, Jiayong Shi, Wenyu Du, Nan Xu, Xiaomin Zhang, Yanming Ji, Peifeng Zhang, Fengyi Jia, Zhen Wang, Yeping Zheng, Zhi Zhang, Hongping Zhao, Fangqing |
author_facet | Wang, Jinfeng Zheng, Jiayong Shi, Wenyu Du, Nan Xu, Xiaomin Zhang, Yanming Ji, Peifeng Zhang, Fengyi Jia, Zhen Wang, Yeping Zheng, Zhi Zhang, Hongping Zhao, Fangqing |
author_sort | Wang, Jinfeng |
collection | PubMed |
description | OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected. To avoid vaginal bacteria contaminations, the included neonates were predominantly delivered by C-section, with their samples collected within seconds of delivery. RESULTS: Numerous and diverse bacterial taxa were identified from the neonatal samples, and the samples from different neonatal body sites were grouped into distinct clusters. The microbiota of pregnant women and neonates was remarkably altered in GDM, with a strong correlation between certain discriminatory bacteria and the oral glucose tolerance test. Microbes varying by the same trend across the maternal and neonatal microbiota were observed, revealing the intergenerational concordance of microbial variation associated with GDM. Furthermore, lower evenness but more depletion of KEGG orthologues and higher abundance of some viruses (eg, herpesvirus and mastadenovirus) were observed in the meconium microbiota of neonates associated with GDM. CONCLUSION: GDM can alter the microbiota of both pregnant women and neonates at birth, which sheds light on another form of inheritance and highlights the importance of understanding the formation of early-life microbiome. |
format | Online Article Text |
id | pubmed-6109274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-61092742018-08-27 Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus Wang, Jinfeng Zheng, Jiayong Shi, Wenyu Du, Nan Xu, Xiaomin Zhang, Yanming Ji, Peifeng Zhang, Fengyi Jia, Zhen Wang, Yeping Zheng, Zhi Zhang, Hongping Zhao, Fangqing Gut Gut Microbiota OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected. To avoid vaginal bacteria contaminations, the included neonates were predominantly delivered by C-section, with their samples collected within seconds of delivery. RESULTS: Numerous and diverse bacterial taxa were identified from the neonatal samples, and the samples from different neonatal body sites were grouped into distinct clusters. The microbiota of pregnant women and neonates was remarkably altered in GDM, with a strong correlation between certain discriminatory bacteria and the oral glucose tolerance test. Microbes varying by the same trend across the maternal and neonatal microbiota were observed, revealing the intergenerational concordance of microbial variation associated with GDM. Furthermore, lower evenness but more depletion of KEGG orthologues and higher abundance of some viruses (eg, herpesvirus and mastadenovirus) were observed in the meconium microbiota of neonates associated with GDM. CONCLUSION: GDM can alter the microbiota of both pregnant women and neonates at birth, which sheds light on another form of inheritance and highlights the importance of understanding the formation of early-life microbiome. BMJ Publishing Group 2018-09 2018-05-14 /pmc/articles/PMC6109274/ /pubmed/29760169 http://dx.doi.org/10.1136/gutjnl-2018-315988 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Gut Microbiota Wang, Jinfeng Zheng, Jiayong Shi, Wenyu Du, Nan Xu, Xiaomin Zhang, Yanming Ji, Peifeng Zhang, Fengyi Jia, Zhen Wang, Yeping Zheng, Zhi Zhang, Hongping Zhao, Fangqing Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title | Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title_full | Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title_fullStr | Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title_full_unstemmed | Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title_short | Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
title_sort | dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus |
topic | Gut Microbiota |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109274/ https://www.ncbi.nlm.nih.gov/pubmed/29760169 http://dx.doi.org/10.1136/gutjnl-2018-315988 |
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