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Memantine has no effect on K(ATP) channels in pancreatic β cells

OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is...

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Autores principales: Imai, Ryota, Misaka, Shingen, Horita, Shoichiro, Yokota, Shoko, O’hashi, Rie, Maejima, Yuko, Shimomura, Kenju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109345/
https://www.ncbi.nlm.nih.gov/pubmed/30144824
http://dx.doi.org/10.1186/s13104-018-3715-9
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author Imai, Ryota
Misaka, Shingen
Horita, Shoichiro
Yokota, Shoko
O’hashi, Rie
Maejima, Yuko
Shimomura, Kenju
author_facet Imai, Ryota
Misaka, Shingen
Horita, Shoichiro
Yokota, Shoko
O’hashi, Rie
Maejima, Yuko
Shimomura, Kenju
author_sort Imai, Ryota
collection PubMed
description OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the K(ATP) channel in pancreatic β cells, it would be an effective drug for both Alzheimer’s disease and diabetes. However, there is no report on the effect of memantine on the K(ATP) channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and K(ATP) channel activity in pancreatic β cells. RESULTS: An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on K(ATP) channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or K(ATP) channel current in pancreatic β cells.
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spelling pubmed-61093452018-08-29 Memantine has no effect on K(ATP) channels in pancreatic β cells Imai, Ryota Misaka, Shingen Horita, Shoichiro Yokota, Shoko O’hashi, Rie Maejima, Yuko Shimomura, Kenju BMC Res Notes Research Note OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the K(ATP) channel in pancreatic β cells, it would be an effective drug for both Alzheimer’s disease and diabetes. However, there is no report on the effect of memantine on the K(ATP) channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and K(ATP) channel activity in pancreatic β cells. RESULTS: An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on K(ATP) channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or K(ATP) channel current in pancreatic β cells. BioMed Central 2018-08-25 /pmc/articles/PMC6109345/ /pubmed/30144824 http://dx.doi.org/10.1186/s13104-018-3715-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Imai, Ryota
Misaka, Shingen
Horita, Shoichiro
Yokota, Shoko
O’hashi, Rie
Maejima, Yuko
Shimomura, Kenju
Memantine has no effect on K(ATP) channels in pancreatic β cells
title Memantine has no effect on K(ATP) channels in pancreatic β cells
title_full Memantine has no effect on K(ATP) channels in pancreatic β cells
title_fullStr Memantine has no effect on K(ATP) channels in pancreatic β cells
title_full_unstemmed Memantine has no effect on K(ATP) channels in pancreatic β cells
title_short Memantine has no effect on K(ATP) channels in pancreatic β cells
title_sort memantine has no effect on k(atp) channels in pancreatic β cells
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109345/
https://www.ncbi.nlm.nih.gov/pubmed/30144824
http://dx.doi.org/10.1186/s13104-018-3715-9
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