Cargando…
Memantine has no effect on K(ATP) channels in pancreatic β cells
OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109345/ https://www.ncbi.nlm.nih.gov/pubmed/30144824 http://dx.doi.org/10.1186/s13104-018-3715-9 |
_version_ | 1783350312488140800 |
---|---|
author | Imai, Ryota Misaka, Shingen Horita, Shoichiro Yokota, Shoko O’hashi, Rie Maejima, Yuko Shimomura, Kenju |
author_facet | Imai, Ryota Misaka, Shingen Horita, Shoichiro Yokota, Shoko O’hashi, Rie Maejima, Yuko Shimomura, Kenju |
author_sort | Imai, Ryota |
collection | PubMed |
description | OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the K(ATP) channel in pancreatic β cells, it would be an effective drug for both Alzheimer’s disease and diabetes. However, there is no report on the effect of memantine on the K(ATP) channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and K(ATP) channel activity in pancreatic β cells. RESULTS: An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on K(ATP) channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or K(ATP) channel current in pancreatic β cells. |
format | Online Article Text |
id | pubmed-6109345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61093452018-08-29 Memantine has no effect on K(ATP) channels in pancreatic β cells Imai, Ryota Misaka, Shingen Horita, Shoichiro Yokota, Shoko O’hashi, Rie Maejima, Yuko Shimomura, Kenju BMC Res Notes Research Note OBJECTIVE: Memantine, a drug for Alzheimer’s disease, is considered to suppress excessive stimulation of N-methyl-d-aspartic acid receptors and to prevent neuronal death. However, a recent report indicated that the neuronal K(ATP) channel also can become a target of memantine. The K(ATP) channel is a key regulator of insulin secretion in pancreatic β cells. Therefore, if memantine could inhibit the K(ATP) channel in pancreatic β cells, it would be an effective drug for both Alzheimer’s disease and diabetes. However, there is no report on the effect of memantine on the K(ATP) channel in pancreatic β cells. Therefore, we investigated whether memantine affect the blood glucose level, insulin secretion and K(ATP) channel activity in pancreatic β cells. RESULTS: An intraperitoneal glucose tolerance test was performed with or without memantine (1 mg/kg) injection in intact mice. Insulin secretion from isolated islets was measured under low (2 mM) and high (20 mM) glucose concentrations with or without memantine (1 μM). The effect of memantine (1 μM) on K(ATP) channel currents in isolated pancreatic β cells was recorded using the whole-cell patch-clamp technique. Memantine had no effect on the blood glucose level, insulin secretion from isolated islets or K(ATP) channel current in pancreatic β cells. BioMed Central 2018-08-25 /pmc/articles/PMC6109345/ /pubmed/30144824 http://dx.doi.org/10.1186/s13104-018-3715-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Imai, Ryota Misaka, Shingen Horita, Shoichiro Yokota, Shoko O’hashi, Rie Maejima, Yuko Shimomura, Kenju Memantine has no effect on K(ATP) channels in pancreatic β cells |
title | Memantine has no effect on K(ATP) channels in pancreatic β cells |
title_full | Memantine has no effect on K(ATP) channels in pancreatic β cells |
title_fullStr | Memantine has no effect on K(ATP) channels in pancreatic β cells |
title_full_unstemmed | Memantine has no effect on K(ATP) channels in pancreatic β cells |
title_short | Memantine has no effect on K(ATP) channels in pancreatic β cells |
title_sort | memantine has no effect on k(atp) channels in pancreatic β cells |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109345/ https://www.ncbi.nlm.nih.gov/pubmed/30144824 http://dx.doi.org/10.1186/s13104-018-3715-9 |
work_keys_str_mv | AT imairyota memantinehasnoeffectonkatpchannelsinpancreaticbcells AT misakashingen memantinehasnoeffectonkatpchannelsinpancreaticbcells AT horitashoichiro memantinehasnoeffectonkatpchannelsinpancreaticbcells AT yokotashoko memantinehasnoeffectonkatpchannelsinpancreaticbcells AT ohashirie memantinehasnoeffectonkatpchannelsinpancreaticbcells AT maejimayuko memantinehasnoeffectonkatpchannelsinpancreaticbcells AT shimomurakenju memantinehasnoeffectonkatpchannelsinpancreaticbcells |