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The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases
Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually l...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109496/ https://www.ncbi.nlm.nih.gov/pubmed/30159340 http://dx.doi.org/10.1155/2018/4892473 |
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author | Bagatini, Margarete Dulce dos Santos, Alessandra Antunes Cardoso, Andréia Machado Mânica, Aline Reschke, Cristina Ruedell Carvalho, Fabiano Barbosa |
author_facet | Bagatini, Margarete Dulce dos Santos, Alessandra Antunes Cardoso, Andréia Machado Mânica, Aline Reschke, Cristina Ruedell Carvalho, Fabiano Barbosa |
author_sort | Bagatini, Margarete Dulce |
collection | PubMed |
description | Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration. These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors. Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The currently available treatments present limited effectiveness and are mostly palliative. This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5′-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer. In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases. Although the role of ectonucleotidases still remains to be further investigated, evidences reviewed here can contribute to a better understanding of the molecular mechanisms of highly complex diseases, which majorly impact on patients' quality of life. |
format | Online Article Text |
id | pubmed-6109496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61094962018-08-29 The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases Bagatini, Margarete Dulce dos Santos, Alessandra Antunes Cardoso, Andréia Machado Mânica, Aline Reschke, Cristina Ruedell Carvalho, Fabiano Barbosa J Immunol Res Review Article Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration. These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors. Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The currently available treatments present limited effectiveness and are mostly palliative. This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5′-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer. In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases. Although the role of ectonucleotidases still remains to be further investigated, evidences reviewed here can contribute to a better understanding of the molecular mechanisms of highly complex diseases, which majorly impact on patients' quality of life. Hindawi 2018-08-12 /pmc/articles/PMC6109496/ /pubmed/30159340 http://dx.doi.org/10.1155/2018/4892473 Text en Copyright © 2018 Margarete Dulce Bagatini et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bagatini, Margarete Dulce dos Santos, Alessandra Antunes Cardoso, Andréia Machado Mânica, Aline Reschke, Cristina Ruedell Carvalho, Fabiano Barbosa The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title | The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title_full | The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title_fullStr | The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title_full_unstemmed | The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title_short | The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases |
title_sort | impact of purinergic system enzymes on noncommunicable, neurological, and degenerative diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109496/ https://www.ncbi.nlm.nih.gov/pubmed/30159340 http://dx.doi.org/10.1155/2018/4892473 |
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