Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expr...

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Detalles Bibliográficos
Autores principales: Pinacchio, Claudia, Scheri, Giuseppe Corano, Statzu, Maura, Santinelli, Letizia, Ceccarelli, Giancarlo, Innocenti, Giuseppe Pietro, Vullo, Vincenzo, Antonelli, Guido, Brenchley, Jason M., d'Ettorre, Gabriella, Scagnolari, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109550/
https://www.ncbi.nlm.nih.gov/pubmed/30186879
http://dx.doi.org/10.1155/2018/1738676
Descripción
Sumario:Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.

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