Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation

Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expr...

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Autores principales: Pinacchio, Claudia, Scheri, Giuseppe Corano, Statzu, Maura, Santinelli, Letizia, Ceccarelli, Giancarlo, Innocenti, Giuseppe Pietro, Vullo, Vincenzo, Antonelli, Guido, Brenchley, Jason M., d'Ettorre, Gabriella, Scagnolari, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109550/
https://www.ncbi.nlm.nih.gov/pubmed/30186879
http://dx.doi.org/10.1155/2018/1738676
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author Pinacchio, Claudia
Scheri, Giuseppe Corano
Statzu, Maura
Santinelli, Letizia
Ceccarelli, Giancarlo
Innocenti, Giuseppe Pietro
Vullo, Vincenzo
Antonelli, Guido
Brenchley, Jason M.
d'Ettorre, Gabriella
Scagnolari, Carolina
author_facet Pinacchio, Claudia
Scheri, Giuseppe Corano
Statzu, Maura
Santinelli, Letizia
Ceccarelli, Giancarlo
Innocenti, Giuseppe Pietro
Vullo, Vincenzo
Antonelli, Guido
Brenchley, Jason M.
d'Ettorre, Gabriella
Scagnolari, Carolina
author_sort Pinacchio, Claudia
collection PubMed
description Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.
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spelling pubmed-61095502018-09-05 Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation Pinacchio, Claudia Scheri, Giuseppe Corano Statzu, Maura Santinelli, Letizia Ceccarelli, Giancarlo Innocenti, Giuseppe Pietro Vullo, Vincenzo Antonelli, Guido Brenchley, Jason M. d'Ettorre, Gabriella Scagnolari, Carolina J Immunol Res Research Article Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation. Hindawi 2018-08-12 /pmc/articles/PMC6109550/ /pubmed/30186879 http://dx.doi.org/10.1155/2018/1738676 Text en Copyright © 2018 Claudia Pinacchio et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pinacchio, Claudia
Scheri, Giuseppe Corano
Statzu, Maura
Santinelli, Letizia
Ceccarelli, Giancarlo
Innocenti, Giuseppe Pietro
Vullo, Vincenzo
Antonelli, Guido
Brenchley, Jason M.
d'Ettorre, Gabriella
Scagnolari, Carolina
Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title_full Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title_fullStr Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title_full_unstemmed Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title_short Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation
title_sort type i/ii interferon in hiv-1-infected patients: expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109550/
https://www.ncbi.nlm.nih.gov/pubmed/30186879
http://dx.doi.org/10.1155/2018/1738676
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