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Inflammation in Right Ventricular Failure: Does It Matter?

Right ventricular (RV) failure is a common consequence of acute and chronic RV overload of pressure, such as after pulmonary embolism and pulmonary hypertension. It has been recently realized that symptomatology and survival of patients with pulmonary hypertension are essentially determined by RV fu...

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Detalles Bibliográficos
Autores principales: Dewachter, Laurence, Dewachter, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109764/
https://www.ncbi.nlm.nih.gov/pubmed/30177883
http://dx.doi.org/10.3389/fphys.2018.01056
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author Dewachter, Laurence
Dewachter, Céline
author_facet Dewachter, Laurence
Dewachter, Céline
author_sort Dewachter, Laurence
collection PubMed
description Right ventricular (RV) failure is a common consequence of acute and chronic RV overload of pressure, such as after pulmonary embolism and pulmonary hypertension. It has been recently realized that symptomatology and survival of patients with pulmonary hypertension are essentially determined by RV function adaptation to increased afterload. Therefore, improvement of RV function and reversal of RV failure are treatment goals. Currently, the pathophysiology and the pathobiology underlying RV failure remain largely unknown. A better understanding of the pathophysiological processes involved in RV failure is needed, as there is no proven treatment for this disease at the moment. The present review aims to summarize the current understanding of the pathogenesis of RV failure, focusing on inflammation. We attempt to formally emphasize the importance of inflammation and associated representative inflammatory molecules and cells in the primum movens and development of RV failure in humans and in experimental models. We present inflammatory biomarkers and immune mediators involved in RV failure. We focus on inflammatory mediators and cells which seem to correlate with the deterioration of RV function and also explain how all these inflammatory mediators and cells might impact RV function adaptation to increased afterload. Finally, we also discuss the evidence on potential beneficial effects of targeted anti-inflammatory agents in the setting of acute and chronic RV failure.
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spelling pubmed-61097642018-09-03 Inflammation in Right Ventricular Failure: Does It Matter? Dewachter, Laurence Dewachter, Céline Front Physiol Physiology Right ventricular (RV) failure is a common consequence of acute and chronic RV overload of pressure, such as after pulmonary embolism and pulmonary hypertension. It has been recently realized that symptomatology and survival of patients with pulmonary hypertension are essentially determined by RV function adaptation to increased afterload. Therefore, improvement of RV function and reversal of RV failure are treatment goals. Currently, the pathophysiology and the pathobiology underlying RV failure remain largely unknown. A better understanding of the pathophysiological processes involved in RV failure is needed, as there is no proven treatment for this disease at the moment. The present review aims to summarize the current understanding of the pathogenesis of RV failure, focusing on inflammation. We attempt to formally emphasize the importance of inflammation and associated representative inflammatory molecules and cells in the primum movens and development of RV failure in humans and in experimental models. We present inflammatory biomarkers and immune mediators involved in RV failure. We focus on inflammatory mediators and cells which seem to correlate with the deterioration of RV function and also explain how all these inflammatory mediators and cells might impact RV function adaptation to increased afterload. Finally, we also discuss the evidence on potential beneficial effects of targeted anti-inflammatory agents in the setting of acute and chronic RV failure. Frontiers Media S.A. 2018-08-20 /pmc/articles/PMC6109764/ /pubmed/30177883 http://dx.doi.org/10.3389/fphys.2018.01056 Text en Copyright © 2018 Dewachter and Dewachter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Dewachter, Laurence
Dewachter, Céline
Inflammation in Right Ventricular Failure: Does It Matter?
title Inflammation in Right Ventricular Failure: Does It Matter?
title_full Inflammation in Right Ventricular Failure: Does It Matter?
title_fullStr Inflammation in Right Ventricular Failure: Does It Matter?
title_full_unstemmed Inflammation in Right Ventricular Failure: Does It Matter?
title_short Inflammation in Right Ventricular Failure: Does It Matter?
title_sort inflammation in right ventricular failure: does it matter?
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109764/
https://www.ncbi.nlm.nih.gov/pubmed/30177883
http://dx.doi.org/10.3389/fphys.2018.01056
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