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Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis

BACKGROUND: Dendritic cell (DC)-derived indolamine 2,3-dioxygenase (IDO) degrades tryptophan to kynurenine, which promotes conversion of inflammatory T cells in immunosuppressive regulatory T cells (Tregs). We analyzed the significance of the IDO:Treg axis for inducing and maintaining mucosal healin...

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Detalles Bibliográficos
Autores principales:	Acovic, Aleksandar, Simovic Markovic, Bojana, Gazdic, Marina, Arsenijevic, Aleksandar, Jovicic, Nemanja, Gajovic, Nevena, Jovanovic, Marina, Zdravkovic, Natasa, Kanjevac, Tatjana, Harrell, C. Randall, Fellabaum, Crissy, Dolicanin, Zana, Djonov, Valentin, Arsenijevic, Nebojsa, Lukic, Miodrag L., Volarevic, Vladislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109841/ https://www.ncbi.nlm.nih.gov/pubmed/30159037 http://dx.doi.org/10.1177/1756284818793558

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