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Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension
Protein ubiquitination serves many regulatory functions; in addition to degradation, ubiquitination has roles in intracellular trafficking, cell cycle, innate immunity, and more. Using mass spectrometry, it is possible to assess the ubiquitination state of every protein simultaneously. In this issue...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109854/ https://www.ncbi.nlm.nih.gov/pubmed/30124137 http://dx.doi.org/10.1177/2045894018796782 |
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author | Rathinasabapathy, Anandharajan West, James D. |
author_facet | Rathinasabapathy, Anandharajan West, James D. |
author_sort | Rathinasabapathy, Anandharajan |
collection | PubMed |
description | Protein ubiquitination serves many regulatory functions; in addition to degradation, ubiquitination has roles in intracellular trafficking, cell cycle, innate immunity, and more. Using mass spectrometry, it is possible to assess the ubiquitination state of every protein simultaneously. In this issue, Wade et al. have for the first time done just that in a hypoxic mouse model of pulmonary hypertension (PH). New techniques drive new discoveries; their work is important not just because they have found new ways to intervene in known PH-related pathways but have found regulation of proteins not previously associated with disease. |
format | Online Article Text |
id | pubmed-6109854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61098542018-08-29 Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension Rathinasabapathy, Anandharajan West, James D. Pulm Circ Review Article Protein ubiquitination serves many regulatory functions; in addition to degradation, ubiquitination has roles in intracellular trafficking, cell cycle, innate immunity, and more. Using mass spectrometry, it is possible to assess the ubiquitination state of every protein simultaneously. In this issue, Wade et al. have for the first time done just that in a hypoxic mouse model of pulmonary hypertension (PH). New techniques drive new discoveries; their work is important not just because they have found new ways to intervene in known PH-related pathways but have found regulation of proteins not previously associated with disease. SAGE Publications 2018-08-20 /pmc/articles/PMC6109854/ /pubmed/30124137 http://dx.doi.org/10.1177/2045894018796782 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Rathinasabapathy, Anandharajan West, James D. Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title | Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title_full | Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title_fullStr | Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title_full_unstemmed | Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title_short | Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
title_sort | ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109854/ https://www.ncbi.nlm.nih.gov/pubmed/30124137 http://dx.doi.org/10.1177/2045894018796782 |
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