A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade

Evidence from mouse chronic viral infection models suggests that CD8(+) T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer...

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Detalles Bibliográficos
Autores principales: Thommen, D.S., Koelzer, V.H., Herzig, P., Roller, A., Trefny, M., Dimeloe, S., Kiialainen, A., Hanhart, J., Schill, C., Hess, C., Savic Prince, S., Wiese, M., Lardinois, D., Ho, P.C., Klein, C., Karanikas, V., Mertz, K.D., Schumacher, T.N., Zippelius, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110381/
https://www.ncbi.nlm.nih.gov/pubmed/29892065
http://dx.doi.org/10.1038/s41591-018-0057-z

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