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Activation of the G(i) protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia

Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in almost all mammalian cells. The canonical Hedgehog (HH) pathway requires trafficking of the G protein-coupled receptor SMOOTHENED (SMO) and the GLI transcription factors to the primary cilium upon bin...

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Detalles Bibliográficos
Autores principales:	Ho Wei, Lan, Arastoo, Mohammad, Georgiou, Ioanna, Manning, David R., Riobo-Del Galdo, Natalia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110505/ https://www.ncbi.nlm.nih.gov/pubmed/30148884 http://dx.doi.org/10.1371/journal.pone.0203170

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