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Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa
INTRODUCTION: One of the most recognized factors of maternal and neonatal outcome pertaining to the peripartum period is the duration of labour. Finding a drug that will decrease the duration of labour with no effects on mother and foetus will be welcomed. Thereby in this study we aimed to evaluate...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110543/ https://www.ncbi.nlm.nih.gov/pubmed/30167045 http://dx.doi.org/10.11604/pamj.2018.30.17.14728 |
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author | Tchente, Charlotte Nguefack Nana, Theophile Njamen Tolefac, Paul Nkemtendong Abanda, Martin Hongieh Angong, Francky Teddy Endomba Tamambang, Rita Frinue Kenfack, Gabin Ulrich Mangala, Georges Nkwelle Muhammad, Sagir Doualla, Marie Solange Belley, Eugene Priso |
author_facet | Tchente, Charlotte Nguefack Nana, Theophile Njamen Tolefac, Paul Nkemtendong Abanda, Martin Hongieh Angong, Francky Teddy Endomba Tamambang, Rita Frinue Kenfack, Gabin Ulrich Mangala, Georges Nkwelle Muhammad, Sagir Doualla, Marie Solange Belley, Eugene Priso |
author_sort | Tchente, Charlotte Nguefack |
collection | PubMed |
description | INTRODUCTION: One of the most recognized factors of maternal and neonatal outcome pertaining to the peripartum period is the duration of labour. Finding a drug that will decrease the duration of labour with no effects on mother and foetus will be welcomed. Thereby in this study we aimed to evaluate the effects of phloroglucinol on the duration of the active phase of labour. METHODS: We did a single blinded placebo controlled randomised 1:1 parallel designed superiority trial between January and June 2017 in Douala general hospital. Participants greater than 18 years with singleton uncomplicated pregnancy who consented following randomisation, were administered either 80mg/8ml intravenous phloroglucinol or 8ml of sterile water when in active labour. The primary outcome was the duration of labour. Modified intention to treat analysis was done with the level of significance set at a p value of 0.05. RESULTS: 122 participants received the intervention. The mean total duration labour in the treatment and placebo group were 216.8 ± 38.7 and 358.5 ± 65.8 respectively (p value = 0.243). The mean duration of the active phase of labour in the treatment and placebo group were 183.0±35.6 and 316.0±52.2 respectively (p value = 0.046). The mean rate of cervical dilatation in the treatment and placebo group were 2.1 ± 0.4 and 1.3 ± 0.4 respectively (p value = 0.322). There was no difference in maternal and foetal outcomes between the two groups. CONCLUSION: Phloroglucinol shortens the duration of active phase of labour by about 2 hours (42%). It is safe to mother and baby and does not cause adverse foetal or maternal outcomes. |
format | Online Article Text |
id | pubmed-6110543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-61105432018-08-30 Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa Tchente, Charlotte Nguefack Nana, Theophile Njamen Tolefac, Paul Nkemtendong Abanda, Martin Hongieh Angong, Francky Teddy Endomba Tamambang, Rita Frinue Kenfack, Gabin Ulrich Mangala, Georges Nkwelle Muhammad, Sagir Doualla, Marie Solange Belley, Eugene Priso Pan Afr Med J Research INTRODUCTION: One of the most recognized factors of maternal and neonatal outcome pertaining to the peripartum period is the duration of labour. Finding a drug that will decrease the duration of labour with no effects on mother and foetus will be welcomed. Thereby in this study we aimed to evaluate the effects of phloroglucinol on the duration of the active phase of labour. METHODS: We did a single blinded placebo controlled randomised 1:1 parallel designed superiority trial between January and June 2017 in Douala general hospital. Participants greater than 18 years with singleton uncomplicated pregnancy who consented following randomisation, were administered either 80mg/8ml intravenous phloroglucinol or 8ml of sterile water when in active labour. The primary outcome was the duration of labour. Modified intention to treat analysis was done with the level of significance set at a p value of 0.05. RESULTS: 122 participants received the intervention. The mean total duration labour in the treatment and placebo group were 216.8 ± 38.7 and 358.5 ± 65.8 respectively (p value = 0.243). The mean duration of the active phase of labour in the treatment and placebo group were 183.0±35.6 and 316.0±52.2 respectively (p value = 0.046). The mean rate of cervical dilatation in the treatment and placebo group were 2.1 ± 0.4 and 1.3 ± 0.4 respectively (p value = 0.322). There was no difference in maternal and foetal outcomes between the two groups. CONCLUSION: Phloroglucinol shortens the duration of active phase of labour by about 2 hours (42%). It is safe to mother and baby and does not cause adverse foetal or maternal outcomes. The African Field Epidemiology Network 2018-05-09 /pmc/articles/PMC6110543/ /pubmed/30167045 http://dx.doi.org/10.11604/pamj.2018.30.17.14728 Text en © Charlotte Nguefack Tchente et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Tchente, Charlotte Nguefack Nana, Theophile Njamen Tolefac, Paul Nkemtendong Abanda, Martin Hongieh Angong, Francky Teddy Endomba Tamambang, Rita Frinue Kenfack, Gabin Ulrich Mangala, Georges Nkwelle Muhammad, Sagir Doualla, Marie Solange Belley, Eugene Priso Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title | Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title_full | Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title_fullStr | Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title_full_unstemmed | Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title_short | Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa |
title_sort | effects of phloroglucinol on the active phase of labour (epal trial): a single blinded randomised controlled trial in a tertiary hospital in sub-sahara africa |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110543/ https://www.ncbi.nlm.nih.gov/pubmed/30167045 http://dx.doi.org/10.11604/pamj.2018.30.17.14728 |
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