Mechanical interactions among followers determine the emergence of leaders in migrating epithelial cell collectives

Regulating the emergence of leaders is a central aspect of collective cell migration, but the underlying mechanisms remain ambiguous. Here we show that the selective emergence of leader cells at the epithelial wound-margin depends on the dynamics of the follower cells and is spatially limited by the...

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Detalles Bibliográficos
Autores principales: Vishwakarma, Medhavi, Di Russo, Jacopo, Probst, Dimitri, Schwarz, Ulrich S., Das, Tamal, Spatz, Joachim P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110746/
https://www.ncbi.nlm.nih.gov/pubmed/30150695
http://dx.doi.org/10.1038/s41467-018-05927-6

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