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Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model

In a rat ex vivo acute glaucoma model, high pressure (75 mmHg) causes swelling of ganglion cell axons and elevates levels of the endogenous steroids 24(S)-hydroxycholesterol (24SH) and allopregnanolone (AlloP). Furthermore, 24SH (0.1 µM) alone elevates AlloP levels via NMDA receptors. With this mode...

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Detalles Bibliográficos
Autores principales:	Ishikawa, Makoto, Yoshitomi, Takeshi, Covey, Douglas F., Zorumski, Charles F., Izumi, Yukitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110753/ https://www.ncbi.nlm.nih.gov/pubmed/30150786 http://dx.doi.org/10.1038/s41598-018-31239-2

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