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A catalogue of somatic NRF2 gain-of-function mutations in cancer

Identification and characterization of somatic mutations in cancer have important prognostication and treatment implications. Genes encoding the Nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor and its negative regulator, Kelch-like ECH-associated protein 1 (KEAP1), are freque...

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Detalles Bibliográficos
Autores principales: Kerins, Michael John, Ooi, Aikseng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110754/
https://www.ncbi.nlm.nih.gov/pubmed/30150714
http://dx.doi.org/10.1038/s41598-018-31281-0