Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model

Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state of NF-kB RelA has been found to...

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Detalles Bibliográficos
Autores principales: Schiaffino, Lorenzo, Bonafede, Roberta, Scambi, Ilaria, Parrella, Edoardo, Pizzi, Marina, Mariotti, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110772/
https://www.ncbi.nlm.nih.gov/pubmed/30150770
http://dx.doi.org/10.1038/s41598-018-30659-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110772/
https://www.ncbi.nlm.nih.gov/pubmed/30150770
http://dx.doi.org/10.1038/s41598-018-30659-4

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