Sexual difference of small RNA expression in Tetralogy of Fallot

Small RNAs, especially the microRNAs, have been revealed to play great roles in heart development and congenital heart defects. Several studies have shown dysregulated miRNAs in ventricular tissues of Tetralogy of Fallot (TOF) patients. In the present study, we conducted high throughput sequencing t...

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Autores principales: Wang, Bo, Shi, Guocheng, Zhu, Zhongqun, Chen, Huiwen, Fu, Qihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110777/
https://www.ncbi.nlm.nih.gov/pubmed/30150777
http://dx.doi.org/10.1038/s41598-018-31243-6
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author Wang, Bo
Shi, Guocheng
Zhu, Zhongqun
Chen, Huiwen
Fu, Qihua
author_facet Wang, Bo
Shi, Guocheng
Zhu, Zhongqun
Chen, Huiwen
Fu, Qihua
author_sort Wang, Bo
collection PubMed
description Small RNAs, especially the microRNAs, have been revealed to play great roles in heart development and congenital heart defects. Several studies have shown dysregulated miRNAs in ventricular tissues of Tetralogy of Fallot (TOF) patients. In the present study, we conducted high throughput sequencing to obtain the global profiling of small RNA transcriptome in heart right ventricular samples from 10 age -matched TOF patients. These samples showed dominant composition of miRNA and mitochondrial associated RNAs. By sRNA cluster identification and differential gene expression analysis, significant sexual difference was discovered for sRNA expression in TOF patients. miR-1/miR-133, which have been identified as essential for cardiac development, account for the most variance of sRNA expression between sexes in TOF hearts.
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spelling pubmed-61107772018-08-30 Sexual difference of small RNA expression in Tetralogy of Fallot Wang, Bo Shi, Guocheng Zhu, Zhongqun Chen, Huiwen Fu, Qihua Sci Rep Article Small RNAs, especially the microRNAs, have been revealed to play great roles in heart development and congenital heart defects. Several studies have shown dysregulated miRNAs in ventricular tissues of Tetralogy of Fallot (TOF) patients. In the present study, we conducted high throughput sequencing to obtain the global profiling of small RNA transcriptome in heart right ventricular samples from 10 age -matched TOF patients. These samples showed dominant composition of miRNA and mitochondrial associated RNAs. By sRNA cluster identification and differential gene expression analysis, significant sexual difference was discovered for sRNA expression in TOF patients. miR-1/miR-133, which have been identified as essential for cardiac development, account for the most variance of sRNA expression between sexes in TOF hearts. Nature Publishing Group UK 2018-08-27 /pmc/articles/PMC6110777/ /pubmed/30150777 http://dx.doi.org/10.1038/s41598-018-31243-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Bo
Shi, Guocheng
Zhu, Zhongqun
Chen, Huiwen
Fu, Qihua
Sexual difference of small RNA expression in Tetralogy of Fallot
title Sexual difference of small RNA expression in Tetralogy of Fallot
title_full Sexual difference of small RNA expression in Tetralogy of Fallot
title_fullStr Sexual difference of small RNA expression in Tetralogy of Fallot
title_full_unstemmed Sexual difference of small RNA expression in Tetralogy of Fallot
title_short Sexual difference of small RNA expression in Tetralogy of Fallot
title_sort sexual difference of small rna expression in tetralogy of fallot
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110777/
https://www.ncbi.nlm.nih.gov/pubmed/30150777
http://dx.doi.org/10.1038/s41598-018-31243-6
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