Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism of initiation is unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal fibroblasts (HADF) and cause extracellular acidification. HMEX were isolate...

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Detalles Bibliográficos
Autores principales: Shu, Shin La, Yang, Yunchen, Allen, Cheryl L., Maguire, Orla, Minderman, Hans, Sen, Arindam, Ciesielski, Michael J., Collins, Katherine A., Bush, Peter J., Singh, Prashant, Wang, Xue, Morgan, Martin, Qu, Jun, Bankert, Richard B., Whiteside, Theresa L., Wu, Yun, Ernstoff, Marc S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110845/
https://www.ncbi.nlm.nih.gov/pubmed/30150674
http://dx.doi.org/10.1038/s41598-018-31323-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110845/
https://www.ncbi.nlm.nih.gov/pubmed/30150674
http://dx.doi.org/10.1038/s41598-018-31323-7

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