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Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue
The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110864/ https://www.ncbi.nlm.nih.gov/pubmed/30150620 http://dx.doi.org/10.1038/s41598-018-31270-3 |
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author | Lee, Jin-Seok Kim, Hyeong-Geug Lee, Dong-Soo Son, Chang-Gue |
author_facet | Lee, Jin-Seok Kim, Hyeong-Geug Lee, Dong-Soo Son, Chang-Gue |
author_sort | Lee, Jin-Seok |
collection | PubMed |
description | The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidative parameters, which included reactive oxygen species (ROS), malondialdehyde (MDA) and F2-isoprotan, and tumor necrosis factor-alpha (TNF-α) were significantly elevated, while antioxidant parameters, which included total antioxidant activity (TAC), catalase, superoxide dismutase, SOD and GSH activity, were decreased compared to those of healthy subjects (by approximately 1.2- to 2.3-fold, p < 0.05 or 0.01). Our results confirmed that oxidative stress is a key contributor in the pathophysiology of ICF, and firstly explored the features of oxidative stress parameters in ICF subjects compared to a healthy population. |
format | Online Article Text |
id | pubmed-6110864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61108642018-08-30 Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue Lee, Jin-Seok Kim, Hyeong-Geug Lee, Dong-Soo Son, Chang-Gue Sci Rep Article The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidative parameters, which included reactive oxygen species (ROS), malondialdehyde (MDA) and F2-isoprotan, and tumor necrosis factor-alpha (TNF-α) were significantly elevated, while antioxidant parameters, which included total antioxidant activity (TAC), catalase, superoxide dismutase, SOD and GSH activity, were decreased compared to those of healthy subjects (by approximately 1.2- to 2.3-fold, p < 0.05 or 0.01). Our results confirmed that oxidative stress is a key contributor in the pathophysiology of ICF, and firstly explored the features of oxidative stress parameters in ICF subjects compared to a healthy population. Nature Publishing Group UK 2018-08-27 /pmc/articles/PMC6110864/ /pubmed/30150620 http://dx.doi.org/10.1038/s41598-018-31270-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lee, Jin-Seok Kim, Hyeong-Geug Lee, Dong-Soo Son, Chang-Gue Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title | Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title_full | Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title_fullStr | Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title_full_unstemmed | Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title_short | Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue |
title_sort | oxidative stress is a convincing contributor to idiopathic chronic fatigue |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110864/ https://www.ncbi.nlm.nih.gov/pubmed/30150620 http://dx.doi.org/10.1038/s41598-018-31270-3 |
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