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M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABA(A) receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis. Impaired KCC2 function accelerates or facilitates seizure onset. Calpain, with two main subtyp...

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Detalles Bibliográficos
Autores principales:	Wan, Li, Ren, Liang, Chen, Lulan, Wang, Guoxiang, Liu, Xu, Wang, Benjamin H., Wang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110871/ https://www.ncbi.nlm.nih.gov/pubmed/30186110 http://dx.doi.org/10.3389/fnmol.2018.00287

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