Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation

Dilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D(5) dopamine receptor (D5R) gene knockout (D5(-/-)) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated ca...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaoliang, Liu, Yunpeng, Liu, Xing, Wang, Wenjie, Wang, Zihao, Hu, Yongyan, Zhang, Yuanyuan, Zhang, Yanrong, Jose, Pedro A., Wei, Qiang, Yang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111036/
https://www.ncbi.nlm.nih.gov/pubmed/30153650
http://dx.doi.org/10.1016/j.redox.2018.07.008

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