AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6

Under intravenous delivery, recombinant adeno-associated vectors (rAAVs) interact with blood-borne components in ways that can critically alter their therapeutic efficiencies. We have previously shown that interaction with human galectin 3 binding protein dramatically reduces rAAV-6 efficacy, wherea...

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Detalles Bibliográficos
Autores principales: Denard, Jérôme, Rouillon, Jérémy, Leger, Thibaut, Garcia, Camille, Lambert, Michele P., Griffith, Graziella, Jenny, Christine, Camadro, Jean-Michel, Garcia, Luis, Svinartchouk, Fedor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111067/
https://www.ncbi.nlm.nih.gov/pubmed/30155509
http://dx.doi.org/10.1016/j.omtm.2018.08.001

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