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Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All die...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111262/ https://www.ncbi.nlm.nih.gov/pubmed/30103487 http://dx.doi.org/10.3390/jcm7080210 |
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author | Zhang, Yiying Qiu, Hongbin |
author_facet | Zhang, Yiying Qiu, Hongbin |
author_sort | Zhang, Yiying |
collection | PubMed |
description | To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females. |
format | Online Article Text |
id | pubmed-6111262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61112622018-08-28 Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia Zhang, Yiying Qiu, Hongbin J Clin Med Article To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females. MDPI 2018-08-11 /pmc/articles/PMC6111262/ /pubmed/30103487 http://dx.doi.org/10.3390/jcm7080210 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Yiying Qiu, Hongbin Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title | Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title_full | Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title_fullStr | Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title_full_unstemmed | Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title_short | Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia |
title_sort | folate, vitamin b6 and vitamin b12 intake in relation to hyperuricemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111262/ https://www.ncbi.nlm.nih.gov/pubmed/30103487 http://dx.doi.org/10.3390/jcm7080210 |
work_keys_str_mv | AT zhangyiying folatevitaminb6andvitaminb12intakeinrelationtohyperuricemia AT qiuhongbin folatevitaminb6andvitaminb12intakeinrelationtohyperuricemia |