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Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia

To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All die...

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Autores principales: Zhang, Yiying, Qiu, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111262/
https://www.ncbi.nlm.nih.gov/pubmed/30103487
http://dx.doi.org/10.3390/jcm7080210
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author Zhang, Yiying
Qiu, Hongbin
author_facet Zhang, Yiying
Qiu, Hongbin
author_sort Zhang, Yiying
collection PubMed
description To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females.
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spelling pubmed-61112622018-08-28 Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia Zhang, Yiying Qiu, Hongbin J Clin Med Article To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females. MDPI 2018-08-11 /pmc/articles/PMC6111262/ /pubmed/30103487 http://dx.doi.org/10.3390/jcm7080210 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yiying
Qiu, Hongbin
Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title_full Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title_fullStr Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title_full_unstemmed Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title_short Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia
title_sort folate, vitamin b6 and vitamin b12 intake in relation to hyperuricemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111262/
https://www.ncbi.nlm.nih.gov/pubmed/30103487
http://dx.doi.org/10.3390/jcm7080210
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