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Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111297/ https://www.ncbi.nlm.nih.gov/pubmed/30096934 http://dx.doi.org/10.3390/jcm7080207 |
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author | Chiu, Hsiao-Chen Wu, Meng-Yu Li, Chao-Hsu Huang, Su-Cheng Yiang, Giou-Teng Yen, Hsuan-Shang Liu, Wei-Lin Li, Chia-Jung Kao, Woei-Yau |
author_facet | Chiu, Hsiao-Chen Wu, Meng-Yu Li, Chao-Hsu Huang, Su-Cheng Yiang, Giou-Teng Yen, Hsuan-Shang Liu, Wei-Lin Li, Chia-Jung Kao, Woei-Yau |
author_sort | Chiu, Hsiao-Chen |
collection | PubMed |
description | Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma. Herein, we describe the case of a 61-year-old woman with a history of recurrent leiomyoma of the uterus who presented with intermittent progressive abdominal pain. The imaging study revealed a huge heterogeneous density mass in the pelvic region with pulmonary and hepatic metastases. Exploratory laparotomy and debulking surgery were performed, and showed the coexistence of DPL and leiomyosarcoma. She died approximately one month after the diagnosis because of rapid progression of pleural effusion due to malignancy. This case highlights the clinical features of DPL and its malignant transformation and metastasis so physicians can make an early diagnosis and provide timely management. |
format | Online Article Text |
id | pubmed-6111297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61112972018-08-28 Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis Chiu, Hsiao-Chen Wu, Meng-Yu Li, Chao-Hsu Huang, Su-Cheng Yiang, Giou-Teng Yen, Hsuan-Shang Liu, Wei-Lin Li, Chia-Jung Kao, Woei-Yau J Clin Med Case Report Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma. Herein, we describe the case of a 61-year-old woman with a history of recurrent leiomyoma of the uterus who presented with intermittent progressive abdominal pain. The imaging study revealed a huge heterogeneous density mass in the pelvic region with pulmonary and hepatic metastases. Exploratory laparotomy and debulking surgery were performed, and showed the coexistence of DPL and leiomyosarcoma. She died approximately one month after the diagnosis because of rapid progression of pleural effusion due to malignancy. This case highlights the clinical features of DPL and its malignant transformation and metastasis so physicians can make an early diagnosis and provide timely management. MDPI 2018-08-09 /pmc/articles/PMC6111297/ /pubmed/30096934 http://dx.doi.org/10.3390/jcm7080207 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Chiu, Hsiao-Chen Wu, Meng-Yu Li, Chao-Hsu Huang, Su-Cheng Yiang, Giou-Teng Yen, Hsuan-Shang Liu, Wei-Lin Li, Chia-Jung Kao, Woei-Yau Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title | Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title_full | Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title_fullStr | Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title_full_unstemmed | Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title_short | Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis |
title_sort | epithelial-mesenchymal transition with malignant transformation leading multiple metastasis from disseminated peritoneal leiomyomatosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111297/ https://www.ncbi.nlm.nih.gov/pubmed/30096934 http://dx.doi.org/10.3390/jcm7080207 |
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