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Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis

Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausa...

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Autores principales: Chiu, Hsiao-Chen, Wu, Meng-Yu, Li, Chao-Hsu, Huang, Su-Cheng, Yiang, Giou-Teng, Yen, Hsuan-Shang, Liu, Wei-Lin, Li, Chia-Jung, Kao, Woei-Yau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111297/
https://www.ncbi.nlm.nih.gov/pubmed/30096934
http://dx.doi.org/10.3390/jcm7080207
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author Chiu, Hsiao-Chen
Wu, Meng-Yu
Li, Chao-Hsu
Huang, Su-Cheng
Yiang, Giou-Teng
Yen, Hsuan-Shang
Liu, Wei-Lin
Li, Chia-Jung
Kao, Woei-Yau
author_facet Chiu, Hsiao-Chen
Wu, Meng-Yu
Li, Chao-Hsu
Huang, Su-Cheng
Yiang, Giou-Teng
Yen, Hsuan-Shang
Liu, Wei-Lin
Li, Chia-Jung
Kao, Woei-Yau
author_sort Chiu, Hsiao-Chen
collection PubMed
description Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma. Herein, we describe the case of a 61-year-old woman with a history of recurrent leiomyoma of the uterus who presented with intermittent progressive abdominal pain. The imaging study revealed a huge heterogeneous density mass in the pelvic region with pulmonary and hepatic metastases. Exploratory laparotomy and debulking surgery were performed, and showed the coexistence of DPL and leiomyosarcoma. She died approximately one month after the diagnosis because of rapid progression of pleural effusion due to malignancy. This case highlights the clinical features of DPL and its malignant transformation and metastasis so physicians can make an early diagnosis and provide timely management.
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spelling pubmed-61112972018-08-28 Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis Chiu, Hsiao-Chen Wu, Meng-Yu Li, Chao-Hsu Huang, Su-Cheng Yiang, Giou-Teng Yen, Hsuan-Shang Liu, Wei-Lin Li, Chia-Jung Kao, Woei-Yau J Clin Med Case Report Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma. Herein, we describe the case of a 61-year-old woman with a history of recurrent leiomyoma of the uterus who presented with intermittent progressive abdominal pain. The imaging study revealed a huge heterogeneous density mass in the pelvic region with pulmonary and hepatic metastases. Exploratory laparotomy and debulking surgery were performed, and showed the coexistence of DPL and leiomyosarcoma. She died approximately one month after the diagnosis because of rapid progression of pleural effusion due to malignancy. This case highlights the clinical features of DPL and its malignant transformation and metastasis so physicians can make an early diagnosis and provide timely management. MDPI 2018-08-09 /pmc/articles/PMC6111297/ /pubmed/30096934 http://dx.doi.org/10.3390/jcm7080207 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chiu, Hsiao-Chen
Wu, Meng-Yu
Li, Chao-Hsu
Huang, Su-Cheng
Yiang, Giou-Teng
Yen, Hsuan-Shang
Liu, Wei-Lin
Li, Chia-Jung
Kao, Woei-Yau
Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title_full Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title_fullStr Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title_full_unstemmed Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title_short Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis
title_sort epithelial-mesenchymal transition with malignant transformation leading multiple metastasis from disseminated peritoneal leiomyomatosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111297/
https://www.ncbi.nlm.nih.gov/pubmed/30096934
http://dx.doi.org/10.3390/jcm7080207
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