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Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

The APO-type proline-arginine-rich host defense peptides exhibit potent in vitro killing parameters against Enterobacteriaceae but not to other bacteria. Because of the excellent in vivo properties against systemic and local infections, attempts are regularly made to further improve the activity spe...

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Detalles Bibliográficos
Autores principales:	Ostorhazi, Eszter, Hoffmann, Ralf, Herth, Nicole, Wade, John D., Kraus, Carl N., Otvos Jr., Laszlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111444/ https://www.ncbi.nlm.nih.gov/pubmed/30186829 http://dx.doi.org/10.3389/fchem.2018.00359

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