Cargando…

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling

Gefitinib, an epidermal growth factor receptor (EGFR)-specific drug, is effective for ~1 year, after which resistance is inevitable. Calpain 2 (CAPN2) is known to serve a role in the drug response and resistance in certain cancer therapies. However, the full function of CAPN2, particularly in non-sm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ge, Fang, Tao, Chang, Meijia, Li, Jing, Hong, Qunying, Bai, Chunxue, Zhou, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111457/ https://www.ncbi.nlm.nih.gov/pubmed/30106446 http://dx.doi.org/10.3892/or.2018.6625

Ejemplares similares

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest
por: Zhou, Jian, et al.
Publicado: (2018)

Knockdown of PLAT enhances the anticancer effect of gefitinib in non-small cell lung cancer
por: Yan, Mengnan, et al.
Publicado: (2020)

Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
por: Zhou, Jian, et al.
Publicado: (2019)

TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells
por: Zhang, Jian, et al.
Publicado: (2016)

Gefitinib upregulates death receptor 5 expression to mediate rmhTRAIL-induced apoptosis in Gefitinib-sensitive NSCLC cell line
por: Yan, Dong, et al.
Publicado: (2015)

Role of Calpain in Apoptosis
por: Momeni, Hamid Reza
Publicado: (2011)

Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity
por: Naruo, Yoshimi, et al.
Publicado: (2011)

Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes
por: Huang, Weiqi, et al.
Publicado: (2017)

Hepatocyte growth factor reduces sensitivity to the epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib, in lung adenocarcinoma cells harboring wild-type EGFR
por: Yang, Hua, et al.
Publicado: (2016)

Gefitinib for Epidermal Growth Factor Receptor Activated Osteoarthritis Subpopulation Treatment
por: Sun, Heng, et al.
Publicado: (2018)

Poor response to gefitinib in lung adenocarcinoma with concomitant epidermal growth factor receptor mutation and anaplastic lymphoma kinase rearrangement
por: Zhou, Jianya, et al.
Publicado: (2015)

Ip-10 Inhibits Epidermal Growth Factor–Induced Motility by Decreasing Epidermal Growth Factor Receptor–Mediated Calpain Activity
por: Shiraha, Hidenori, et al.
Publicado: (1999)

Gefitinib (‘Iressa’, ZD1839) and new epidermal growth factor receptor inhibitors
por: Blackledge, G, et al.
Publicado: (2004)

Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment
por: Zhang, Guoyou, et al.
Publicado: (2011)

Osmostress-Induced Apoptosis in Xenopus Oocytes: Role of Stress Protein Kinases, Calpains and Smac/DIABLO
por: Messaoud, Nabil Ben, et al.
Publicado: (2015)

Calpain Activator Dibucaine Induces Platelet Apoptosis
por: Zhang, Weilin, et al.
Publicado: (2011)

Calpain Is a Major Regulator of Neutrophils Apoptosis
por: Altznauer, Frank, et al.
Publicado: (2001)

Calpains in cyanobacteria and the origin of calpains
por: Vešelényiová, Dominika, et al.
Publicado: (2022)

YY1 Knockdown Relieves the Differentiation Block and Restores Apoptosis in AML Cells
por: Noguera, Nelida Ines, et al.
Publicado: (2023)

Restricting extracellular Ca(2+) on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca(2+) response, which consequently enhances gefitinib sensitivity
por: Kim, Mi Seong, et al.
Publicado: (2020)

Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis
por: Park, Seong Ho, et al.
Publicado: (2013)

Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation
por: Nurwidya, Fariz, et al.
Publicado: (2016)

Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas
por: Sumi, Toshiyuki, et al.
Publicado: (2018)

Knockdown of BAP31 Overcomes Hepatocellular Carcinoma Doxorubicin Resistance through Downregulation of Survivin
por: Liu, Jingjing, et al.
Publicado: (2023)

Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy
por: Wang, Tao, et al.
Publicado: (2019)

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
por: Noguchi, Masafumi, et al.
Publicado: (2023)

Oncolytic adenovirus mediated Survivin knockdown by RNA interference suppresses human colorectal carcinoma growth in vitro and in vivo
por: Shen, Wei, et al.
Publicado: (2009)

An otoprotective role for the apoptosis inhibitor protein survivin
por: Knauer, S K, et al.
Publicado: (2010)

Docosahexaenoic Acid Serving As Sensitizing Agents And Gefitinib Resistance Revertants In EGFR Targeting Treatment
por: Ding, Xuansheng, et al.
Publicado: (2019)

Survivin induces defects in apoptosis in eosinophils in intestine with food allergy
por: Gao, Han, et al.
Publicado: (2019)

Symmetrical drug-related intertriginous and flexural exanthema secondary to epidermal growth factor receptor inhibitor gefitinib
por: Copps, Beatrice, et al.
Publicado: (2020)

Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents
por: Garrison, Jason B, et al.
Publicado: (2015)

Enhanced gefitinib‐induced repression of the epidermal growth factor receptor pathway by ataxia telangiectasia‐mutated kinase inhibition in non‐small‐cell lung cancer cells
por: Misumi, Keizo, et al.
Publicado: (2016)

Enhanced Inhibition of Bladder Cancer Cell Growth by Simultaneous Knockdown of Antiapoptotic Bcl-xL and Survivin in Combination with Chemotherapy
por: Kunze, Doreen, et al.
Publicado: (2013)

Inhibition of calpain reduces cell apoptosis by suppressing mitochondrial fission in acute viral myocarditis
por: Shi, Hui, et al.
Publicado: (2021)

Metabolic Glycoengineering Sensitizes Drug-Resistant Pancreatic Cancer Cells to Tyrosine Kinase Inhibitors Erlotinib and Gefitinib
por: Mathew, Mohit P., et al.
Publicado: (2015)

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy
por: Cheung, Chun Hei Antonio, et al.
Publicado: (2010)

Calpain-2 participates in the process of calpain-1 inactivation
por: Shinkai-Ouchi, Fumiko, et al.
Publicado: (2020)

TP53 mutations in circulating tumor DNA in advanced epidermal growth factor receptor-mutant lung adenocarcinoma patients treated with gefitinib
por: Yu, Ruofei, et al.
Publicado: (2021)

Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells
por: Bernaudo, Stefanie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_todc1109ek27dr5gpu23dnsp05