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Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling

Gefitinib, an epidermal growth factor receptor (EGFR)-specific drug, is effective for ~1 year, after which resistance is inevitable. Calpain 2 (CAPN2) is known to serve a role in the drug response and resistance in certain cancer therapies. However, the full function of CAPN2, particularly in non-sm...

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Detalles Bibliográficos
Autores principales:	Zhang, Ge, Fang, Tao, Chang, Meijia, Li, Jing, Hong, Qunying, Bai, Chunxue, Zhou, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111457/ https://www.ncbi.nlm.nih.gov/pubmed/30106446 http://dx.doi.org/10.3892/or.2018.6625

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