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Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study
Objective: The use of serum ammonia as a novel marker for sepsis compared to lactic acid levels in intensive care unit (ICU) patients. Design and Interventions: Single arm, prospective clinical trial to collect arterial blood samples from patients with sepsis. Serial ammonia and lactic acid levels w...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111562/ https://www.ncbi.nlm.nih.gov/pubmed/30049989 http://dx.doi.org/10.3390/jcm7080182 |
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author | Numan, Yazan Jawaid, Yasir Hirzallah, Hisham Kusmic, Damir Megri, Mohammad Aqtash, Obadah Amro, Ahmed Mezughi, Haitem Maher, Emmon Raru, Yonas Numan, Jamil Akpanudo, Sutoidem Khitan, Zeid Shweihat, Yousef |
author_facet | Numan, Yazan Jawaid, Yasir Hirzallah, Hisham Kusmic, Damir Megri, Mohammad Aqtash, Obadah Amro, Ahmed Mezughi, Haitem Maher, Emmon Raru, Yonas Numan, Jamil Akpanudo, Sutoidem Khitan, Zeid Shweihat, Yousef |
author_sort | Numan, Yazan |
collection | PubMed |
description | Objective: The use of serum ammonia as a novel marker for sepsis compared to lactic acid levels in intensive care unit (ICU) patients. Design and Interventions: Single arm, prospective clinical trial to collect arterial blood samples from patients with sepsis. Serial ammonia and lactic acid levels were sent every six hours for a total of three days. Measurements and results: Compare mean levels of ammonia and lactic acid in terms of diagnosing sepsis and patient outcome, including length of stay and mortality. A total of 30 patients were enrolled in the pilot study. On admission, mean ammonia level was 35.7 μmol/L and lactic acid was 3.06 mmole/L. Ammonia levels checked at the end of day 2 (ammonia 2-4) and the beginning of day 3 (ammonia 3-1) were higher in patients who had a microbial culture-proven sepsis (p-values 0.029 and 0.002, respectively) compared to those without culture-positive sepsis. Ammonia levels did predict a longer hospital stay; ammonia level of more than 40 μmol/L had a mean hospital stay of 17.6 days vs. patients with normal levels who had a mean hospital stay of 9.62 days (p-value 0.0082). Conclusion: Elevated ammonia level can be a novel biomarker for sepsis, comparable to conventional markers. Ammonia levels have a prognostic utility as elevated levels were associated with longer hospital stay. |
format | Online Article Text |
id | pubmed-6111562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61115622018-08-28 Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study Numan, Yazan Jawaid, Yasir Hirzallah, Hisham Kusmic, Damir Megri, Mohammad Aqtash, Obadah Amro, Ahmed Mezughi, Haitem Maher, Emmon Raru, Yonas Numan, Jamil Akpanudo, Sutoidem Khitan, Zeid Shweihat, Yousef J Clin Med Article Objective: The use of serum ammonia as a novel marker for sepsis compared to lactic acid levels in intensive care unit (ICU) patients. Design and Interventions: Single arm, prospective clinical trial to collect arterial blood samples from patients with sepsis. Serial ammonia and lactic acid levels were sent every six hours for a total of three days. Measurements and results: Compare mean levels of ammonia and lactic acid in terms of diagnosing sepsis and patient outcome, including length of stay and mortality. A total of 30 patients were enrolled in the pilot study. On admission, mean ammonia level was 35.7 μmol/L and lactic acid was 3.06 mmole/L. Ammonia levels checked at the end of day 2 (ammonia 2-4) and the beginning of day 3 (ammonia 3-1) were higher in patients who had a microbial culture-proven sepsis (p-values 0.029 and 0.002, respectively) compared to those without culture-positive sepsis. Ammonia levels did predict a longer hospital stay; ammonia level of more than 40 μmol/L had a mean hospital stay of 17.6 days vs. patients with normal levels who had a mean hospital stay of 9.62 days (p-value 0.0082). Conclusion: Elevated ammonia level can be a novel biomarker for sepsis, comparable to conventional markers. Ammonia levels have a prognostic utility as elevated levels were associated with longer hospital stay. MDPI 2018-07-26 /pmc/articles/PMC6111562/ /pubmed/30049989 http://dx.doi.org/10.3390/jcm7080182 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Numan, Yazan Jawaid, Yasir Hirzallah, Hisham Kusmic, Damir Megri, Mohammad Aqtash, Obadah Amro, Ahmed Mezughi, Haitem Maher, Emmon Raru, Yonas Numan, Jamil Akpanudo, Sutoidem Khitan, Zeid Shweihat, Yousef Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title | Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title_full | Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title_fullStr | Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title_full_unstemmed | Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title_short | Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study |
title_sort | ammonia vs. lactic acid in predicting positivity of microbial culture in sepsis: the alps pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111562/ https://www.ncbi.nlm.nih.gov/pubmed/30049989 http://dx.doi.org/10.3390/jcm7080182 |
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