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Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression
PURPOSE: To compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma. METHODS: The study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 years to develop a computer simulation mode...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111742/ https://www.ncbi.nlm.nih.gov/pubmed/30159212 http://dx.doi.org/10.1167/tvst.7.4.20 |
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author | Wu, Zhichao Medeiros, Felipe A. |
author_facet | Wu, Zhichao Medeiros, Felipe A. |
author_sort | Wu, Zhichao |
collection | PubMed |
description | PURPOSE: To compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma. METHODS: The study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 years to develop a computer simulation model of “real-world” visual field results. Progression was evaluated with point-wise event-based analysis using the Guided Progression Analysis (GPA) and global trend-based analysis using the mean deviation (MD) and visual field index (VFI) measures. The specificities of the methods were matched based on a simulated dataset of stable glaucoma eyes, to allow an adequate comparison of their sensitivities for detecting progression. RESULTS: The 5-year cumulative false-positive rate for the GPA alert of “possible progression” and “likely progression” (significant change from baseline at two and three consecutive visits, respectively) were 34.0% and 7.0%, respectively. At matched specificities, 27.7% eyes were detected as having progressed after 5 years using the GPA “likely progression” criterion, while 24.6% and 23.8% were detected as having progressed using the global trend–based analysis with MD and VFI, respectively. There was a moderate level of agreement between the GPA and global trend-based analyses. CONCLUSIONS: Pointwise event-based and global trend–based methods had similar performances to detect glaucoma progression when rigorously matched for specificity. TRANSLATIONAL RELEVANCE: Although both point-wise event- and global trend–based analyses perform similarly, they could provide complementary information that could be exploited to improve the overall detection of progression in clinical practice and clinical trials. |
format | Online Article Text |
id | pubmed-6111742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61117422018-08-29 Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression Wu, Zhichao Medeiros, Felipe A. Transl Vis Sci Technol Articles PURPOSE: To compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma. METHODS: The study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 years to develop a computer simulation model of “real-world” visual field results. Progression was evaluated with point-wise event-based analysis using the Guided Progression Analysis (GPA) and global trend-based analysis using the mean deviation (MD) and visual field index (VFI) measures. The specificities of the methods were matched based on a simulated dataset of stable glaucoma eyes, to allow an adequate comparison of their sensitivities for detecting progression. RESULTS: The 5-year cumulative false-positive rate for the GPA alert of “possible progression” and “likely progression” (significant change from baseline at two and three consecutive visits, respectively) were 34.0% and 7.0%, respectively. At matched specificities, 27.7% eyes were detected as having progressed after 5 years using the GPA “likely progression” criterion, while 24.6% and 23.8% were detected as having progressed using the global trend–based analysis with MD and VFI, respectively. There was a moderate level of agreement between the GPA and global trend-based analyses. CONCLUSIONS: Pointwise event-based and global trend–based methods had similar performances to detect glaucoma progression when rigorously matched for specificity. TRANSLATIONAL RELEVANCE: Although both point-wise event- and global trend–based analyses perform similarly, they could provide complementary information that could be exploited to improve the overall detection of progression in clinical practice and clinical trials. The Association for Research in Vision and Ophthalmology 2018-08-27 /pmc/articles/PMC6111742/ /pubmed/30159212 http://dx.doi.org/10.1167/tvst.7.4.20 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Articles Wu, Zhichao Medeiros, Felipe A. Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title | Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title_full | Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title_fullStr | Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title_full_unstemmed | Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title_short | Comparison of Visual Field Point-Wise Event-Based and Global Trend-Based Analysis for Detecting Glaucomatous Progression |
title_sort | comparison of visual field point-wise event-based and global trend-based analysis for detecting glaucomatous progression |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111742/ https://www.ncbi.nlm.nih.gov/pubmed/30159212 http://dx.doi.org/10.1167/tvst.7.4.20 |
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