ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Activation of p38 mitogen‐activated protein kinase (MAPK) and c‐Jun amino terminal kinase (JNK) is prominent in human crescentic glomerulonephritis. p38 and JNK inhibitors suppress crescentic disease in animal models; however, the upstream mechanisms inducing activation of these kinases in crescenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111820/
https://www.ncbi.nlm.nih.gov/pubmed/29998485
http://dx.doi.org/10.1111/jcmm.13705

Ejemplares similares

Ejemplares similares